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首页> 美国卫生研究院文献>Brain Sciences >Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females
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Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females

机译：面部悲伤识别是由健康女性中的雌激素受体基因多态性调节的。

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摘要

Polymorphisms of the estrogen receptor ESR1 and ESR2 genes have been linked with cognitive deficits and affective disorders. The effects of these genetic variants on emotional processing in females with low estrogen levels are not well known. The aim was to explore the impact of the ESR1 and ESR2 genes on the responses to the facial emotion recognition task in females. Postmenopausal healthy female volunteers were genotyped for the polymorphisms Xbal and PvuII of ESR1 and the polymorphism rs1256030 of ESR2. The effect of these polymorphisms on the response to the facial emotion recognition of the emotions happiness, sadness, disgust, anger, surprise, and fear was analyzed. Females carrying the P allele of the PvuII polymorphism or the X allele of the Xbal polymorphism of ESR1 easily recognized facial expressions of sadness that were more difficult for the women carrying the p allele or the x allele. They displayed higher accuracy, fast response time, more correct responses, and fewer omissions to complete the task, with a large effect size. Women carrying the ESR2 C allele of ESR2 showed a faster response time for recognizing facial expressions of anger. These findings link ESR1 and ESR2 polymorphisms in facial emotion recognition of negative emotions.
机译：雌激素受体ESR1和ESR2基因的多态性与认知缺陷和情感障碍有关。这些遗传变异对雌激素水平低的女性情绪加工的影响尚不清楚。目的是探讨ESR1和ESR2基因对女性面部表情识别任务的反应的影响。对绝经后健康女性志愿者的ESR1基因多态性Xbal和PvuII和ESR2基因多态性rs1256030进行基因分型。分析了这些多态性对面部表情的响应的影响，这些表情包括情绪的幸福，悲伤，厌恶，愤怒，惊奇和恐惧。携带ESR1 PvuII多态性的P等位基因或Xbal多态性的X等位基因的女性容易识别悲伤的面部表情，而这些面部表情对于携带p等位基因或x等位基因的女性而言则更为困难。他们显示出更高的准确性，更快的响应时间，更正确的响应以及更少的遗漏来完成任务，并且效果很大。携带ESR2的ESR2 C等位基因的女性在识别愤怒的面部表情时显示出更快的响应时间。这些发现将ESR1和ESR2多态性链接到了负面情绪的面部情绪识别中。

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