Estrogen Receptor Gene Polymorphisms and Breast Cancer Risk

机译：雌激素受体基因多态性与乳腺癌风险

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

Purpose: to test the hypothesis that individual variation in the sensitivity to estrogens whether from endogenous or exogenous sources, affects woman's risk of breast cancer. Scope: to test if the variability in responses to estrogens in women may be determined by a functionally significant variation in the estrogen receptor alpha (ER) though which estrogens exert biologic effects. The ER polymorphism under study are: Xba-I, Pvu II and microsattelite polymorphism. In an exploratory analysis we will study the interaction between the Xba I, Pvu II and microsatellite ER polymorphism and estrogen-related risk factors for breast cancer such as reproductive history and menopausal hormone use. Major findings: not yet available biological sample collection and laboratory analysis still ongoing. Up-to-date report of the progress in terms of results and significance: no results are yet available - we are still collecting biological samples, extracting DNA from the biological materials (leukocytes and pathological slides) and processing the laboratory analysis. These activities are following the time schedule as stated in the Proposal to the Army. We expect to have preliminary results by the spring of year 2001.

著录项

作者
Adami, H. G.;
展开▼
作者单位

展开▼
年度 2000
页码 1-10
总页数 10
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Hormones; Polymorphism; Reproduction(Physiology); Estrogens; Breast cancer; Risk; Biology; Sensitivity; Deoxyribonucleic acids; Genes; Hypotheses; Women;

机译：激素;多态性;繁殖（生理学）;雌激素;乳腺癌;风险;生物学;敏感性;脱氧核糖核酸;基因;假设;女性;

相似文献

外文文献
中文文献
专利

1. Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease [J] . Lisa Gallicchio, Sonja I Berndt, Meghan A McSorley, BMC Cancer . 2006,第1期

机译：一群患有良性乳腺疾病的女性人群中雌激素代谢和雌激素受体基因的多态性与患乳腺癌的风险
2. Possible difference in frequencies of genetic polymorphisms of estrogen receptor alpha, estrogen metabolism and P53 genes between estrogen receptor-positive and -negative breast cancers. [J] . Hamaguchi M, Nishio M, Toyama T, Japanese journal of clinical oncology. . 2008,第11期

机译：在雌激素受体阳性和阴性乳腺癌之间，雌激素受体α，雌激素代谢和P53基因的遗传多态性的频率可能存在差异。
3. Possible Difference in Frequencies of Genetic Polymorphisms of Estrogen Receptor α, Estrogen Metabolism and P53 Genes Between Estrogen Receptor-positive and -negative Breast Cancers [J] . Maho Hamaguchi Mariko Nishio Tatsuya Toyama Hiroshi Sugiura Naoto Kondo Yoshitaka Fujii and Hiroko Yamashita Japanese Journal of Clinical Oncology . 2008,第11期

机译：雌激素受体阳性和阴性乳腺癌之间雌激素受体α，小鼠雌激素代谢和P53基因多态性频率的可能差异
4. Polymorphism of the Estrogen Receptor-p Gene in Breast Cancer [C] . Cristina Caraion, Nadine Vincent, Claude Lambert, International Symposium on Hormonal Carcinogenesis . 2005

机译：乳腺癌雌激素受体-P基因的多态性
5. Estrogens, genetic polymorphisms and breast cancer risk in Nigerian women. [D] . Okobia, Michael N. 2005

机译：尼日利亚妇女的雌激素，遗传多态性和乳腺癌风险。
6. Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease [O] . Lisa Gallicchio, Sonja I Berndt, Meghan A McSorley, 2006

机译：一群患有良性乳腺疾病的女性人群中雌激素代谢和雌激素受体基因的多态性与患乳腺癌的风险
7. Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease [O] . Lisa Gallicchio, Sonja I Berndt, Meghan A McSorley, 2006

机译：一群患有良性乳腺疾病的女性人群中雌激素代谢和雌激素受体基因的多态性与患乳腺癌的风险

Estrogen Receptor Gene Polymorphisms and Breast Cancer Risk

摘要

著录项

相似文献

相关主题

期刊订阅