首页> 美国卫生研究院文献>The Journal of Physiology >Topographical localization in the motor cortex of the cat for somatic afferent responses and evoked movements.
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Topographical localization in the motor cortex of the cat for somatic afferent responses and evoked movements.

机译:在猫的运动皮层中进行体位传入反应和诱发运动的地形定位。

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摘要

Microwires chronically implanted in the pericruciate cortex of free-to-move cats were used to record extracellularly from cortical neurones and to deliver intracortical stimulation. Natural stimulation of cutaneous and/or deep mechanoreceptors in limbs and trunk evoked discharges in 89% of 165 neurones, 57% of which were pyramidal tract neurones. Out of 112 cells with receptive fields on the contralateral forelimb, 41% had cutaneous fields, 29% had fields involving deep tissues and 30% were driven from both sources. Cutaneous receptive fields were much commoner than deep ones among cells with fields including the forefoot; this relationship was reversed for cells with more proximal fields. Many more cells had distal than proximal fields. The 'zones' of the forelimb (i.e. foot, wrist, elbow, shoulder) provided input to widespread and overlapping cell populations within the coronal gyrus and the lateral parts of the anterior and posterior sigmoid gyri. Despite the overlap a somatotopy existed with successively more distal limb zones represented successively further laterally in the pericruciate area. Intracortical stimulation (eleven cathodal pulses, duration 0.2 ms, frequency 330 Hz, intensity 35 microA or less) evoked flick movements of the contralateral limbs which were abolished by pyramidectomy. In the forelimb, shoulder movements were commonest and elbow, wrist and digits were represented with decreasing frequency. Both for 35 microA and for threshold stimulation the distributions of the effective electrodes revealed an overlapping somatotopy such that the wrist movements were almost restricted to the coronal gyrus and shoulder movements were most often evoked from the lateral part of the anterior sigmoid gyrus. The movement and receptive field somatotopies overlapped heavily but the former showed a distinct lateral shift relative to the latter. As a result shoulder movements were not uncommonly evoked from the coronal gyrus although the shoulder provided almost no input to cells in that area.
机译:长期植入自由移动的猫的圆锥形皮层中的微线用于记录皮层神经元的细胞外信号并传递皮层内刺激。在165个神经元中,有89%受到自然刺激的四肢和躯干引起的皮肤和/或深层机械感受器放电,其中57%为锥体束神经元。在对侧前肢中具有接受区域的112个细胞中,有41%具有皮肤区域,有29%具有涉及深部组织的区域,有30%来自这两种来源。在包括前足在内的区域中,皮肤的感受野比深部的普遍得多。对于近端视野更多的细胞,这种关系被逆转。远侧视野比近侧视野更多。前肢的“区域”(即脚,腕,肘,肩)为冠状回以及乙状窦前,后乙状结肠的外侧部分中广泛且重叠的细胞群提供了输入。尽管有重叠,但仍存在一个体解剖学,其周围的远端肢体区域在周缘区域中依次在横向上依次更远。皮质内刺激(11个阴极脉冲,持续时间0.2 ms,频率330 Hz,强度35 microA或更小)引起了对侧肢体的轻弹运动,而该运动被锥体切除术所消除。在前肢中,肩部运动最为常见,肘部,腕部和手指的运动频率降低。对于35 microA和阈值刺激,有效电极的分布都显示出重叠的体型,因此腕部运动几乎仅限于冠状回,而肩部运动最常从前乙状回的外侧引起。运动和接受场的体细胞学是重迭的,但是前者相对于后者表现出明显的横向偏移。结果,尽管肩部几乎不向该区域的细胞提供任何输入,但冠状回并没有引起肩部运动。

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