Safety tolerability pharmacokinetics and pharmacodynamics of losmapimod following a single intravenous or oral dose in healthy volunteers

机译：健康志愿者中单次静脉内或口服给药后洛沙莫德的安全性耐受性药代动力学和药效学

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摘要

AimsThe purpose of this study was to establish safety and tolerability of a single intravenous (IV) infusion of a p38 mitogen-activated protein kinase inhibitor, losmapimod, to obtain therapeutic levels rapidly for a potential acute coronary syndrome indication. Pharmacokinetics (PK) following IV dosing were characterized, and pharmacokinetic/pharmacodynamic (PK/PD) relationships between losmapimod and phosphorylated heat shock protein 27 (pHSP27) and high-sensitivity C-reactive protein were explored.

机译：目的本研究的目的是确定单次静脉（IV）输注p38丝裂原活化蛋白激酶抑制剂losmapimod的安全性和耐受性，以快速获得潜在的急性冠状动脉综合征指征的治疗水平。表征了静脉内给药后的药代动力学（PK），并探讨了洛沙莫莫德和磷酸化热休克蛋白27（pHSP27）与高敏C反应蛋白之间的药代动力学/药效学（PK / PD）关系。

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期刊名称 British Journal of Clinical Pharmacology
作者
April M Barbour; Lea Sarov-Blat; Gengqian Cai; Michael J Fossler; Dennis L Sprecher; Johann Graggaber; Adam T McGeoch; Jo Maison; Joseph Cheriyan;
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作者单位

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年(卷),期 2013(76),1
年度 2013
页码 99–106
总页数 8
原文格式 PDF
正文语种
中图分类药学;
关键词
losmapimod pharmacodynamics pharmacokinetics;

机译：losmapimod;药效动力学;药代动力学;

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专利

1. Safety, tolerability, pharmacokinetics and pharmacodynamics of losmapimod following a single intravenous or oral dose in healthy volunteers [J] . April M. Barbour, Lea Sarov-Blat, Gengqian Cai, British journal of clinical pharmacology . 2013,第1期

机译：健康志愿者中单次静脉内或口服给药后洛沙莫德的安全性，耐受性，药代动力学和药效学
2. Vedolizumab Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability Following Administration of a Single, Ascending, Intravenous Dose to Healthy Volunteers [J] . Rosario Maria, Wyant Timothy, Leach Timothy, Clinical drug investigation . 2016,第11期

机译：向健康志愿者服用单一，递增，静脉内剂量后，维多珠单抗的药代动力学，药代动力学，安全性和耐受性
3. Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Evaluations Following Single Oral Doses of GSK2330672 in Healthy Japanese Volunteers [J] . Hiroko Ino, Akira Endo, Akira Wakamatsu, Clinical pharmacology in drug development . 2019,第1期

机译：在健康日本志愿者中单次口服剂量的GSK2330672之后的安全性，耐受性，药代动力学和药效学评价
4. Safety, tolerability, pharmacodynamics and pharmacokinetics following single subcutaneous dosesof a teverelix depot formulation in healthy male volunteers [C] . C. MacLean, F. Larsen, R. Piechatzek, Annual meeting exposition of the Controlled Release Society . 2005

机译：在健康男性志愿者中单次皮下注射Teverelix储库制剂后的安全性，耐受性，药效动力学和药代动力学
5. Propafenone pharmacokinetics: GLC-ECD analysis; metabolic induction by phenobarbital in nonsmoking and smoking healthy volunteers; protein binding; pharmacodynamics in patients [D] . Chan, Grace Lap-Yu 1989

机译：普罗帕酮药代动力学：GLC-ECD分析；非吸烟和吸烟健康志愿者的苯巴比妥诱导代谢；蛋白质结合；患者的药效学
6. Safety tolerability pharmacokinetics and pharmacodynamics of single oral doses of BI 187004 an inhibitor of 11beta-hydroxysteroid dehydrogenase-1 in healthy male volunteers with overweight or obesity [O] . Susanna Bianzano, Tim Heise, Arvid Jungnik, 2021

机译：单次口服剂量乳头剂量的安全性耐受性药代动力学和药效学11beta-羟类脱氢酶-1的抑制剂具有超重或肥胖的健康男性志愿者
7. Safety, tolerability, pharmacokinetics and pharmacodynamics of losmapimod following a single intravenous or oral dose in healthy volunteers [O] . April M. Barbour, Lea Sarov-Blat, Gengqian Cai, 2013

机译：在健康志愿者中单个静脉内或口服剂量后洛昔偶莫德的安全性，耐受性，药代动力学和药效学

Safety tolerability pharmacokinetics and pharmacodynamics of losmapimod following a single intravenous or oral dose in healthy volunteers

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