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首页> 美国卫生研究院文献>The Journal of Physiology >Changes in global cerebral blood flow in humans: effect on regional cerebral blood flow during a neural activation task.
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Changes in global cerebral blood flow in humans: effect on regional cerebral blood flow during a neural activation task.

机译：人类整体脑血流量的变化：在神经激活任务中对区域脑血流量的影响。

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1. The primary objective of this study was to examine in man, how induced changes in global cerebral blood flow (gCBF) affected a regional cerebral blood flow (rCBF) increase resulting from a neural activation task (opening of eyes). A secondary objective was to quantify how such induced changes in gCBF were distributed between representative regions of either predominantly grey matter or white matter. 2. Positron emission tomography with intravenous infusion of H2(15)O, was used to measure gCBF in six normal males. Concomitant measures of rCBF were obtained in three different regions of interest (ROI): a representative area of predominantly grey matter, a representative area of predominantly white matter and an area of visual cortex. 3. Cerebral blood flow was altered by establishing steady-state changes in PCO2 at a near constant ventilation of approximately 30 l min-1. The mean PET,CO2 (+/- S.D.) levels (mmHg) that resulted were: low, 21.8 +/- 1.8; normal, 39.8 +/- 1.0, and high, 54.8 +/- 1.2. The normal and high levels were obtained by adding appropriate amounts of CO2 to the inspirate. The corresponding mean gCBF levels across all six subjects with eyes closed were: low, 24.2 +/- 4.6; normal, 37.2 +/- 3.9 and high, 66.8 +/- 7.6 ml min-1 dl-1. 4. Blood flow in grey matter (insular cortex) and white matter (centrum semiovale) at normal levels of PCO2 averaged 56.8 +/- 10.1 and 20.3 +/- 3.4 ml min dl-1 respectively. As PCO2 rose, the increase in rCBF to grey matter was approximately three times greater than that to white matter. 5. An activation state of eyes open in a brightly lit room was compared to a baseline state of eyes closed in a darkened room at the three levels of PCO2 (and hence at three levels of gCBF). Over the whole gCBF range a significant (P = 0.028) effect of increasing rCBF in the visual cortex ROI was found in response to opening the eyes; the effect of this activation on rCBF was not significantly dependent (P = 0.34) on the PCO2 (and hence gCBF) level. The effect of the activation on the rCBF was apparently 'additive' to the rise of rCBF associated with PCO2-related gCBF increase. 6. The results confirm the need to normalize for changes in gCBF during studies of rCBF in response to an activation protocol. They also provide support for the use of an 'additive' model to achieve such normalization provided that other cortical areas behave in a similar manner to that of the visual cortex.
机译：1.这项研究的主要目的是在人中研究由于神经激活任务（睁开眼睛）而引起的全球脑血流量（gCBF）的变化如何影响局部脑血流量（rCBF）的增加。第二个目的是量化gCBF的这种诱导变化如何在主要是灰质或白质的代表性区域之间分布。 2.使用正电子发射断层显像和静脉内输注H2（15）O来测量六名正常男性的gCBF。在三个不同的感兴趣区域（ROI）中获得了rCBF的相应测量值：主要是灰质的代表性区域，主要是白质的代表性区域和视觉皮层区域。 3.通过在大约30 l min-1的恒定通气量下建立PCO2的稳态变化来改变脑血流量。产生的平均PET，CO2（+/- S.D.）水平（mmHg）为：低，21.8 +/- 1.8;正常，39.8 +/- 1.0和高54.8 +/- 1.2。正常和高水平是通过向吸气管中加入适量的二氧化碳来获得的。所有六位闭眼受试者的平均gCBF水平分别为：低，24.2 +/- 4.6，正常，37.2 +/- 3.9和高，66.8 +/- 7.6 ml min-1 dl-1。 4.在正常PCO2水平下，灰质（岛状皮层）和白质（中叶半空心）的血流量分别平均为56.8 +/- 10.1和20.3 +/- 3.4 ml min dl-1。当PCO2上升时，rCBF升高到灰质的速度大约是白质的三倍。 5.将在明亮的房间中睁开的眼睛的激活状态与在黑暗的房间中在三个PCO2水平下（因此在三个gCBF水平）闭眼的基线状态进行比较。在整个gCBF范围内，响应睁开眼睛，发现在视觉皮层ROI中增加rCBF的显着（P = 0.028）效应；该激活对rCBF的影响与PCO2（以及因此的gCBF）水平无关（P = 0.34）。激活对rCBF的影响显然是与PCO2相关的gCBF升高相关的rCBF升高的“加法”。 6.结果证实，在研究rCBF以响应激活方案的过程中，有必要标准化gCBF的变化。它们还为使用“加性”模型实现这种标准化提供了支持，前提是其他皮质区域的行为与视觉皮质的行为相似。

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