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首页> 外文期刊>The European Journal of Neuroscience >The human startle reflex and pons activation: a regional cerebral blood flow study.
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The human startle reflex and pons activation: a regional cerebral blood flow study.

机译：人类惊吓反射和脑桥激活：一项区域性脑血流研究。

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摘要

Using positron emission tomographic measurements of regional cerebral blood flow, we report activation of a medial pons area in humans during acoustic startle stimulation. Eight healthy volunteers were scanned during rest and when presented startle-eliciting stimuli. We performed a theory-driven directed search for activity in the nucleus reticularis pontis caudalis, situated in the pons. Because habituation of cerebellar activity during acoustic startle repetition has been reported [Timmann, D., Musso, C., Kolb, F.P., Rijntjes, M., Juptner, M., Muller, S.P., Diener, H.C. & Weiller, C. (1998) J. Neurol. Neurosurg. Psychiatry 65, 771-773], we also predicted habituation in the cerebellum and in the pons as a function of startle repetition. Measurements of eye electromyography validated the presence of a startle response and its habituation. Analysis of regional cerebral blood flow revealed higher neural activity during startle stimulation than at rest in a medial pons area consistent with the location of the pontine reticular nucleus. As a consequence of startle repetition, regional cerebral blood flow increased in the medial cerebellum, and habituated in the ventral cerebellum and in a ventral pons area separate from the pontine reticular nucleus. In the ventral pons, but not in the pontine reticular nucleus, regional cerebral blood flow and the startle reflex were positively correlated. In the cerebellum both positive and negative correlations with the startle reflex were observed. Thus we conclude that the neurofunctional correlates of the startle circuit and its habituation in humans are similar to that previously described in animals.
机译：使用区域脑血流的正电子发射断层扫描测量，我们报告了在听觉惊吓刺激过程中人类中脑桥区域的激活。八名健康志愿者在休息时和出现惊吓刺激时进行了扫描。我们进行了理论驱动的定向搜索，以搜索位于桥脑中的网状脑桥脑桥尾中的活动。因为已经报道了在听觉惊吓重复过程中小脑活动的习惯化[Timmann，D.，Musso，C.，Kolb，F.P.，Rijntjes，M.，Juptner，M.，Muller，S.P.，Diener，H.C. ＆Weiller，C。（1998）神经病学杂志。神经外科。 Psychiatry 65，771-773]，我们还预测了小脑和脑桥的惯性是惊吓重复的函数。眼肌电图的测量证实了惊吓反应的存在及其习惯。对局部脑血流的分析显示，在惊吓刺激期间，与桥脑网状核位置一致的内侧桥区域的神经活动高于静息状态。惊吓重复的结果是，小脑内侧的局部脑血流量增加，并在小脑腹侧和与脑桥网状核分开的腹桥区域习惯了。在腹桥而不是在桥脑网状核中，区域性脑血流量与惊吓反射呈正相关。在小脑中，与惊吓反射都观察到正相关和负相关。因此，我们得出的结论是，惊吓回路的神经功能相关性及其在人类中的习惯与先前在动物中描述的类似。

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