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首页> 外文期刊>The Journal of Nuclear Medicine >Absolute changes in regional cerebral blood flow in association with upright posture in humans: an orthostatic PET study.
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Absolute changes in regional cerebral blood flow in association with upright posture in humans: an orthostatic PET study.

机译：与人类直立姿势相关的局部脑血流的绝对变化：体位性PET研究。

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摘要

To determine whether hemodynamic parameters are changed by upright posture in healthy middle-aged humans, absolute values of regional cerebral blood flow (rCBF) were investigated for three different orthostatic conditions. METHODS: PET with [15O]H2O and arterial blood sampling were performed on eight middle-aged healthy volunteers while they were sitting passively or standing actively. Absolute rCBF values estimated by the autoradiographic method in regions of interest were compared using ANOVA, and relative changes in rCBF were also analyzed voxel by voxel using statistical parametric mapping (SPM). RESULTS: Physiologic data remained unchanged for different conditions. ANOVA and SPM showed that absolute and relative rCBF levels were significantly elevated in the cerebellar vermis in the standing position compared with those in the supine and sitting positions. In contrast, ANOVA showed that rCBF in the frontal and parietal cortices tended to be lower in the sitting and standing positions than in the supine position. Regression analysis showed that the frontal rCBF measured during standing tended to be inversely correlated with age. CONCLUSION: The results showed that cerebellar vermis activation was more marked in the standing position than in the sitting or supine positions, indicating that the vermis is a neural substrate for controlling voluntary upright posture. Brain perfusion in the distal internal carotid artery region may be subject to orthostatic postural changes in healthy middle-aged humans.
机译：为了确定健康的中年人的直立姿势是否会改变血流动力学参数，针对三种不同的直立性条件研究了局部脑血流（rCBF）的绝对值。方法：对八名健康的中年自愿者，无论他们被动坐着还是主动站立，进行[15O] H2O PET和动脉血采样。使用ANOVA比较通过放射照相法估计的感兴趣区域中的绝对rCBF值，并使用统计参数映射（SPM）逐像素分析rCBF的相对变化。结果：不同条件下的生理数据保持不变。方差分析和SPM表明，与仰卧和坐位相比，站立时小脑ver部的rCBF绝对和相对rCBF水平显着提高。相反，方差分析表明，坐位和站立位的额叶和顶叶皮层中的rCBF倾向于低于仰卧位。回归分析表明，站立时测得的额叶rCBF与年龄呈负相关。结论：结果表明，站立时小脑ver的激活比坐姿或仰卧位更明显，这表明ver是控制随意直立姿势的神经基质。在健康的中年人中，颈内动脉远端区域的脑灌注可能会发生体位性姿势变化。

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