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首页> 美国卫生研究院文献>The British Journal of Ophthalmology >Slope analysis of the optic disc in eyes with ocular hypertension and early normal tension glaucoma by confocal scanning laser ophthalmoscope
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Slope analysis of the optic disc in eyes with ocular hypertension and early normal tension glaucoma by confocal scanning laser ophthalmoscope

机译：共聚焦扫描激光检眼镜分析高眼压和早期正常张力性青光眼的视盘斜率

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摘要

AIMS—To determine whether quantitative differences in sector based slope can differentiate between eyes with ocular hypertension with and without glaucomatous disc changes and eyes with normal tension glaucoma with glaucomatous disc changes.
METHODS—Seventy six eyes with ocular hypertension or early glaucomatous disc changes were consecutively categorised into three groups: 22 eyes with ocular hypertension and no glaucomatous disc changes (OHND); 35 with ocular hypertension and glaucomatous disc changes (OHD); and 19 with normal ocular tension and glaucomatous disc changes (NTD). Twenty eyes served as controls. The average total slope angle and sector based slope angle of the cup, total contour area, effective area, neuroretinal rim area, half depth area, cup to disc ratio, contour variation, mean contour depth, average depth, volume below, half depth volume, and contour tilt were evaluated with a confocal scanning laser ophthalmoscope.
RESULTS—The earliest changes in eyes with OHND or OHD started in the slope at the nasal inferior sector (p<0.05), followed by the superior and temporal superior sectors (p<0.05). The mean slopes in eyes with NTD and OHD were steeper than in controls (p<0.05). Statistically significant differences were found between controls and disease groups in the half depth area, mean contour depth, and half depth volume. The cup to disc ratios in eyes with OHD and NTD were greater than in eyes with OHND; the volume below was greater in eyes with NTD than in eyes with OHND and OHD.
CONCLUSIONS—The steep slope in the nasal inferior section is the first indicator of glaucomatous nerve defects in many eyes. The half depth parameters, half depth area, and half depth volume may be useful for distinguishing ocular hypertension with and without glaucomatous disc changes.
机译：目的：确定基于扇形的斜率的定量差异是否能区分有无青光眼视盘改变的高眼压眼和有青光眼视盘改变的正常眼压性青光眼。视盘变化被连续分为三组：22眼高眼压且无青光眼视盘变化（OHND）; 35岁患有高眼压和青光眼视盘改变（OHD）;和19正常眼压和青光眼视盘改变（NTD）。二十只眼睛作为对照。杯子的平均总倾斜角和基于扇区的倾斜角，总轮廓区域，有效区域，神经视网膜边缘区域，半深度区域，杯与盘的比率，轮廓变化，平均轮廓深度，平均深度，下方体积，半深度体积结果，使用OHND或OHD的最早的眼部改变始于鼻下界的斜率（p <0.05），其次是上视和颞上视个扇区（p <0.05）。患有NTD和OHD的眼睛的平均斜率比对照组的陡峭（p <0.05）。在对照组和疾病组之间，在半深度区域，平均轮廓深度和半深度体积上发现了统计学上的显着差异。 OHD和NTD眼的杯盘比大于OHND眼。 NTD眼的下方容积比OHND和OHD的眼更大。
结论—鼻下节的陡坡是许多眼青光眼神经缺损的首个指标。半深度参数，半深度面积和半深度体积对于区分有无青光眼性椎间盘改变的高眼压可能有用。

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