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首页> 美国卫生研究院文献>The British Journal of Ophthalmology >Long term treatment with sodium hyaluronate-containing artificial tears reduces ocular surface damage in patients with dry eye
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Long term treatment with sodium hyaluronate-containing artificial tears reduces ocular surface damage in patients with dry eye

机译：长期用含透明质酸钠的人工泪液治疗可减轻干眼症患者的眼表损伤

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>Background/aims: Several studies have reported that sodium hyaluronate is able to improve both symptoms and signs in patients with dry eye but none have demonstrated an improvement of conjunctival epithelial cell abnormalities of the ocular surface. The aim of this study was to explore the effect of sodium hyaluronate-containing eye drops on the ocular surface of patients with dry eye during long term treatment.>Methods: A randomised double blind study was undertaken in 86 patients with medium to severe dry eye (that is, rose bengal and/or fluorescein test score of at least 3, tear film break up time <10 seconds, or Schirmer's test <5.5 mm). Patients were treated with either preservative-free sodium hyaluronate or saline for 3 months at a dose of one drop 4–8 times a day. Bulbar impression cytology, slit lamp examinations, and subjective symptoms were evaluated after 1, 2, and 3 months. Impression cytology was considered the primary efficacy parameter of the study.>Results: The efficacy analysis was performed on a total of 44 patients who were able to fully adhere to the protocol. After 3 months of treatment sodium hyaluronate improved impression cytology score (p = 0.024 v baseline). At the same time also the difference with respect to placebo was statistically significant (p = 0.036). Study medication was well tolerated and no treatment related adverse events occurred during the study.>Conclusions: Sodium hyaluronate may effectively improve ocular surface damage associated with dry eye syndrome.
机译：>背景/目的：几项研究报道，透明质酸钠能够改善干眼症患者的症状和体征，但没有一项能够改善眼表结膜上皮细胞异常。这项研究的目的是探讨长期治疗期间含透明质酸钠的滴眼液对干眼患者眼表的影响。>方法：对86例患者进行了随机双盲研究中度至重度干眼（即玫瑰色孟加拉和/或荧光素测试评分至少为3，泪膜破裂时间<10秒，或Schirmer测试<5.5 mm）。用无防腐剂的透明质酸钠或生理盐水治疗患者3个月，每天1滴，每次4至8次。在1、2和3个月后评估球囊印模细胞学，裂隙灯检查和主观症状。印象细胞学被认为是该研究的主要功效参数。>结果：对总共44例完全遵守方案的患者进行了功效分析。治疗3个月后，透明质酸钠改善了印模细胞学评分（p = 0.024 v基线）。同时，安慰剂的差异也具有统计学意义（p = 0.036）。研究药物耐受性良好，研究期间未发生与治疗相关的不良事件。>结论：透明质酸钠可能有效改善与干眼综合征相关的眼表损伤。

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