• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>The British Journal of Ophthalmology >Detection of human papillomavirus DNA in pterygia from different geographical regions
【2h】

Detection of human papillomavirus DNA in pterygia from different geographical regions

机译：不同地区翼状肉中人乳头瘤病毒DNA的检测

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

>Background/aims: The aetiology and pathogenesis of pterygia remain unclear and the involvement of human papillomavirus (HPV) is controversial. 41 pterygia from two geographic locations were evaluated for the presence of HPV DNA.>Methods: 41 pterygium biopsies (17 from Italy and 24 from Ecuador) were analysed using the L1C1 and PU-1ML primer sets by polymerase chain reaction (PCR) and DNA sequence analysis.>Results: 22 of the 41 pterygia (54%) were positive for HPV, including all 17 Italian cases and 5/24 (21%) Ecuadorean cases. DNA sequencing of the 22 positive cases showed that 11 were HPV type 52, four were type 54, five were candHPV90, and two of unknown genotype.>Conclusions: The major differences in the frequency of HPV in geographically distant populations might suggest a possible explanation for the vast differences in the reported detection rates. Three subtypes of HPV were found in this sample of pterygia. None the less, these results suggest that HPV may have a pathogenic role in pterygium.
机译：>背景/目的：翼状gia肉的病因和发病机制仍不清楚，人类乳头瘤病毒（HPV）的参与尚存争议。对来自两个地理位置的41例翼状肉进行了HPV DNA评估。反应（PCR）和DNA序列分析。>结果：41例翼状gia肉中有22例（54％）呈HPV阳性，包括全部17例意大利病例和5/24例（21％）厄瓜多尔病例。 22例阳性病例的DNA测序表明，有11例是52型HPV，4例是54型，5例是candHPV90，还有2例基因型未知。>结论：地理位置较远的HPV频率的主要差异人群可能对所报告的检出率的巨大差异提出了可能的解释。在翼状gia肉的样本中发现了三种HPV亚型。然而，这些结果表明HPV可能在翼状ery肉中具有致病作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号