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首页> 美国卫生研究院文献>The British Journal of Ophthalmology >Indomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing
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Indomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing

机译：消炎痛可降低视神经的氧气张力并降低碳酸酐酶抑制作用和二氧化碳呼吸的作用

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>Background/aims: Prostaglandins are important in blood flow regulation. Carbon dioxide (CO2) breathing and carbonic anhydrase inhibition increase the oxygen tension in the retina and optic nerve. To study the mechanism of this effect and the role of cyclo-oxygenase in the regulation of optic nerve oxygen tension (ONPO2), the authors investigated how indomethacin affects ONPO2 and the ONPO2 increases caused by CO2 breathing and carbonic anhydrase inhibition in the pig.>Methods: Optic nerve oxygen tension was measured in 11 pigs with a polarographic oxygen electrode. The tip of the electrode was placed 0.5 mm above the optic disc. The effects of indomethacin, CO2 breathing (3%) before and after indomethacin treatment, and carbonic anhydrase inhibition with or without indomethacin treatment were investigated.>Results: Administration of 300 mg indomethacin decreased optic nerve oxygen tension significantly. Carbonic anhydrase inhibition and CO2 breathing increased ONPO2 significantly. After indomethacin had been given, the rise in ONPO2 caused by CO2 breathing and carbonic anhydrase inhibition was significantly reduced.>Conclusion: Systemic administration of indomethacin decreases the optic nerve oxygen tension; this is probably the result of decreased blood flow through vasoconstriction of vessels in the optic nerve. Additionally, indomethacin diminishes the ONPO2 increasing effect of CO2 breathing and carbonic anhydrase inhibition, thus affecting the reactivity of vessels in the optic nerve.
机译：>背景/目的：前列腺素在调节血流中很重要。二氧化碳（CO2）呼吸和碳酸酐酶抑制作用会增加视网膜和视神经中的氧气张力。为了研究这种作用的机理以及环加氧酶在调节视神经氧气张力（ONPO2）中的作用，作者研究了吲哚美辛如何影响ONPO2以及猪因CO2呼吸和碳酸酐酶抑制引起的ONPO2增加。< strong>方法：用极谱氧电极测量11头猪的视神经氧张力。将电极的尖端放置在视盘上方0.5 mm处。研究了吲哚美辛，吲哚美辛治疗前后的CO2呼吸（3％）以及有或没有吲哚美辛治疗对碳酸酐酶的抑制作用。>结果：服用300 mg吲哚美辛可显着降低视神经氧张力。碳酸酐酶抑制作用和CO2呼吸显着增加ONPO2。给予吲哚美辛后，由二氧化碳呼吸和抑制碳酸酐酶引起的ONPO2升高显着降低。>结论：全身服用吲哚美辛可降低视神经的氧张力；这可能是由于视神经血管收缩引起的血流量减少的结果。此外，消炎痛降低了COPO呼吸和碳酸酐酶抑制作用对ONPO2的增加作用，从而影响了视神经血管的反应性。

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