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首页> 美国卫生研究院文献>British Journal of Cancer >Uptake of 11C-methionine in breast cancer studied by PET. An association with the size of S-phase fraction.
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Uptake of 11C-methionine in breast cancer studied by PET. An association with the size of S-phase fraction.

机译：PET研究的乳腺癌中11 C-蛋氨酸的摄取。与S相分数的大小相关。

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摘要

L-[methyl-11-C]methionine (11C-methionine) uptake of seven primary breast cancers, four soft tissue metastases of breast cancer, and three other breast lesions was studied by positron emission tomography (PET). 11C-methionine accumulation was assessed by calculating the standardised uptake value (SUV). The mean SUV for breast cancer was 8.5 +/- 3.3 (s.d.), while the maximal uptake in the liver was 12.4 +/- 1.6, in the bone marrow 5.8 +/- 0.7, and in the myocardium 3.4 +/- 0.6. All eight malignant tumours larger than 30 mm in diameter accumulated clearly 11C-methionine, whereas none of the three smaller cancers (from 12 to 15 mm in diameter) were visualised. Strong uptake of 11C-methionine was associated with a large S-phase fraction (SPF) measured with flow cytometry (r = 0.77, P = 0.01), and the non-visualised cancers had all a small SPF (less than 5.5%). One benign tumour (an abscess) accumulated slightly 11C-methionine. The results indicate that both primary and metastatic breast cancer can be effectively imaged with 11C-methionine by PET, and that the accumulation of 11C-methionine may correlate with the proliferation rate of breast carcinoma.
机译：通过正电子发射断层扫描（PET）研究了7种原发性乳腺癌，4种乳腺癌的软组织转移以及3种其他乳腺病变的L- [甲基-11-C]蛋氨酸（11C-蛋氨酸）摄入量。通过计算标准化摄取值（SUV）评估11 C-蛋氨酸的积累。乳腺癌的平均SUV为8.5 +/- 3.3（标准差），而肝脏的最大摄取量为12.4 +/- 1.6，骨髓为5.8 +/- 0.7，心肌为3.4 +/- 0.6。直径大于30毫米的所有八种恶性肿瘤均清楚地积聚11 C-蛋氨酸，而三种较小的癌症（直径从12至15毫米）均未见。流式细胞仪检测到的11C-甲硫氨酸的大量摄取与大的S期分数（SPF）有关（r = 0.77，P = 0.01），非可视化癌症的SPF都很小（小于5.5％）。 1例良性肿瘤（脓肿）微积聚11 C-蛋氨酸。结果表明11C-蛋氨酸可以通过PET有效地成像，并且11C-蛋氨酸的积累可能与乳腺癌的增殖率相关。

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