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首页> 美国卫生研究院文献>British Journal of Cancer >Anticoagulant treatment does not affect the action of flavone acetic acid in tumour-bearing mice.
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Anticoagulant treatment does not affect the action of flavone acetic acid in tumour-bearing mice.

机译：抗凝治疗不会影响荷瘤小鼠中黄酮乙酸的作用。

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摘要

Flavone acetic acid (FAA) is a novel antitumour agent that has a profound effect on the vasculature in murine tumour models. Previously we have shown that FAA induces a coagulopathy and thrombocytopaenia in tumour-bearing mice, and the purpose of the present study was to determine the significance of the FAA-induced intravascular coagulation in the antitumour action of FAA. Several anticoagulant agents were tested for their effectiveness in altering ex vivo coagulation of murine plasma; heparin and ancrod were found to be most effective. These agents were administered to tumour-bearing mice prior to FAA and TNF treatment with little effect on the induced regrowth delay. However: the FAA-induced consumption of platelets in tumour-bearing mice was not blocked by anticoagulant treatment. These data suggest that platelet consumption occurs independently of the normal coagulation pathway, and further that fibrin deposition may not be a major factor in the antitumour action of FAA.
机译：黄酮乙酸（FAA）是一种新型抗肿瘤剂，对鼠肿瘤模型的脉管系统具有深远的影响。先前我们已经证明，FAA会在荷瘤小鼠中诱发凝血病和血小板减少症，并且本研究的目的是确定FAA诱导的血管内凝血在FAA的抗肿瘤作用中的意义。测试了几种抗凝剂在改变鼠血浆离体凝血方面的有效性；肝素和丙烯醛被认为是最有效的。在FAA和TNF治疗之前，将这些药物施用于荷瘤小鼠，对诱导的再生延迟几乎没有影响。但是：FAA诱导的荷瘤小鼠血小板的消耗并未被抗凝治疗所阻断。这些数据表明血小板消耗独立于正常的凝血途径而发生，并且进一步地，纤维蛋白沉积可能不是FAA的抗肿瘤作用的主要因素。

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