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首页> 美国卫生研究院文献>British Journal of Cancer >Influence of the antioestrogen tamoxifen on normal breast tissue.
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Influence of the antioestrogen tamoxifen on normal breast tissue.

机译：抗雌激素他莫昔芬对正常乳腺组织的影响。

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Immunohistochemical assays have been employed to study the expression of ER, PgR, EGFR and Ki67 immunostaining in normal breast tissue (n = 76). The expression of ER and PgR was highly variable in both pre and postmenopausal women and was characterised by large numbers of apparently negative cells. This was most evident for ER-ICA staining in tissues removed from premenopausal women. PgR levels were highest in the ducts of premenopausal women, while EGFR expression was elevated in both ducts and lobules. Ki67 expression was observed in less than 10% of all normal cells and was suppressed by the menopause in lobular tissue. Tamoxifen therapy (40 mg d-1) did not influence the expression of PgR, EGFR or Ki67 immunostaining in cancer associated normal tissue (n = 17). A significant increase, however, was observed in the mean percentage ER positivity in ductal tissue. No effect of duration of tamoxifen therapy was observed on the expression of the antigens studied.
机译：免疫组织化学测定法已用于研究正常乳腺组织（n = 76）中ER，PgR，EGFR和Ki67免疫染色的表达。绝经前和绝经后妇女中ER和PgR的表达变化很大，其特征是大量的明显阴性细胞。这对于绝经前妇女切除的组织中的ER-ICA染色最为明显。绝经前妇女导管中的PgR水平最高，而导管和小叶中的EGFR表达均升高。在少于10％的所有正常细胞中观察到Ki67表达，并在小叶组织中被更年期抑制。他莫昔芬疗法（40 mg d-1）不影响癌症相关正常组织中的PgR，EGFR或Ki67免疫表达（n = 17）。然而，在导管组织中观察到平均ER阳性百分比显着增加。没有观察到他莫昔芬治疗持续时间对所研究抗原的表达的影响。

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