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首页> 美国卫生研究院文献>British Journal of Cancer >Contacts between adults as evidence for an infective origin of childhood leukaemia: an explanation for the excess near nuclear establishments in west Berkshire?
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Contacts between adults as evidence for an infective origin of childhood leukaemia: an explanation for the excess near nuclear establishments in west Berkshire?

机译：成人之间的接触可以证明是儿童白血病的传染源：对伯克希尔西部附近核设施过多的解释？

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The increasing tendency for people to work outside their home community--one of the most striking of modern demographic changes--has relevance to a recent aetiological hypothesis about childhood leukaemia: that a community's immune response to an underlying infection can be disturbed by increases in new social contacts. This was tested in the only 28 former county boroughs in which accurate comparisons of workplace data from the 1971 and 1981 censuses are possible--because their boundaries were left unaltered by the major reorganisation in 1974. After ranking the districts according to extent of commuting increase, a significant trend in leukaemia incidence was found at ages 0-14 (P less than 0.05) and a suggestive one at ages 0-4 (P = 0.055). Among ten similar sized groups of county districts ranked by commuting increase, the only significant increases (P less than 0.001) of leukaemia in 1972-85 at ages 0-4 and 0-14 were in the highest tenth for commuting increase. These excesses persisted after excluding Reading, a major part of an area where an excess of leukaemia has been linked to the nearby nuclear establishments at Aldermaston and Burghfield. This whole area has experienced greater commuting increases than 90% of county districts in England and Wales. The findings are consistent with other evidence supporting the above hypothesis; they also suggest that contacts between adults may influence the incidence of leukaemia in children.
机译：人们在家庭社区以外工作的趋势日益增加-这是现代人口变化中最惊人的变化-与最近有关儿童白血病的病因学假说有关：社区对潜在感染的免疫反应可能会受到感染的增加的干扰。新的社交联系。在仅有的28个前郡县进行了测试，可以对1971年和1981年人口普查的工作场所数据进行精确比较，因为1974年的重大改组没有改变其边界。根据通勤增加的程度对各区进行排名之后，在0-14岁时发现白血病发生率有显着趋势（P小于0.05），而在0-4岁时则提示存在白血病（P = 0.055）。在按通勤增加量排名的十个相似大小的县区组中，1972-85年0-4岁和0-14岁的白血病唯一显着增加（P小于0.001）在通勤增加量中排在最高的第十位。在排除雷丁之后，这些过剩现象仍然存在，雷丁是该地区大部分白血病与附近的Aldermaston和Burghfield核设施有关的地区。与英格兰和威尔士90％的县区相比，这整个地区的通勤人数增加幅度更大。这些发现与支持上述假设的其他证据是一致的；他们还建议成年人之间的接触可能会影响儿童白血病的发病率。

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