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首页> 美国卫生研究院文献>British Journal of Cancer >Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck.
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Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck.

机译：P53表达升高与头颈部鳞状细胞癌中重度吸烟史有关。

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摘要

Expression of the tumour suppressor gene p53 was examined in squamous cell carcinoma of the head and neck using two p53 antibodies, PAb 421 and PAb 1801. Elevated p53 expression was found in 67% of the 73 patients investigated. P53 expression was not found to correlate with whether the patient had been previously treated or not, nor any of the clinico-pathological parameters. However a correlation was found between the patients smoking history and positive p53 staining. Six out of seven non-smokers did not express p53 whereas 29 of 37 heavy smokers were found to have elevated p53 expression (P less than 0.005). Also, of a group of ten patients who had given up smoking more than 5 years ago, nine had elevated expression. Epidemiological studies have shown a correlation between heavy smoking and head and neck cancer. The present study indicate a genetic link for this correlation.
机译：使用两种p53抗体PAb 421和PAb 1801在头颈部鳞状细胞癌中检测了抑癌基因p53的表达。在调查的73例患者中，有67％的人发现p53表达升高。未发现P53表达与患者是否曾接受过治疗或任何临床病理参数有关。然而，发现患者的吸烟史与p53阳性染色之间存在相关性。 7名不吸烟者中有6名不表达p53，而37名重度吸烟者中有29名p53表达升高（P小于0.005）。此外，在十名戒烟超过五年的患者中，九名患者的表达升高。流行病学研究表明，大量吸烟与头颈癌之间存在相关性。本研究表明这种关联的遗传联系。

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