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首页> 美国卫生研究院文献>British Journal of Cancer >Histological features DNA content and prognosis of breast carcinoma found incidentally or in screening.
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Histological features DNA content and prognosis of breast carcinoma found incidentally or in screening.

机译：偶然发现或筛查发现的乳腺癌的组织学特征DNA含量和预后。

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摘要

Histology features, the nuclear DNA content and prognosis of 42 female breast carcinomas found in a physical examination based screening, 54 breast cancers found incidentally by medical personnel, and 274 breast cancers first suspected by the patient were compared. There was no significant difference in the distribution by primary tumour size (P = 0.08) or histological type (P = 0.87) of breast cancer between the screen-detected and 139 self-suspected cancers of women with similar mean age and living at the same time in the same city, but the screen-detected carcinomas were better differentiated (P = 0.0002), and had less mitoses (P = 0.008), less tumour necrosis (P = 0.004) and DNA aneuploidy (P = 0.01), smaller S-phase fractions (P = 0.009), less axillary metastases (P = 0.04), and had better outcome (P = 0.005) than self-suspected carcinomas. These parameters did not differ significantly between the screen-detected and incidentally found cancers, but incidental cancers had more often axillary metastases (P = 0.02). The results indicate that screen-detected breast carcinomas have favourable biological features suggesting low degree of malignant potential.
机译：比较了通过体格检查发现的42例女性乳腺癌的组织学特征，核DNA含量和预后，医务人员偶然发现的54例乳腺癌以及患者首先怀疑的274例乳腺癌。经筛查发现的和平均年龄相似且生活在相同年龄的妇女的139名自测癌症之间，按乳腺癌的原发肿瘤大小（P = 0.08）或组织学类型（P = 0.87）的分布没有显着差异。在同一城市的时间，但筛查到的癌症分化更好（P = 0.0002），有丝分裂（P = 0.008），肿瘤坏死（P = 0.004）和DNA非整倍性（P = 0.01）少，S较小分期分数（P = 0.009），较少的腋窝转移瘤（P = 0.04）和比自我怀疑的癌症更好的结局（P = 0.005）。这些参数在筛查到的癌症和偶然发现的癌症之间没有显着差异，但是偶然的癌症更常发生腋窝转移（P = 0.02）。结果表明，经筛查的乳腺癌具有良好的生物学特征，提示其潜在的恶性程度低。

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