首页> 美国卫生研究院文献>Bosnian Journal of Basic Medical Sciences >ROLE OF MECONIUM IN THE REACTION OF AIRWAYS SMOOTH MUSCULATURE IN THE NEWBORN WITH MECONIUM ASPIRATION SYNDROME (MAS)
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ROLE OF MECONIUM IN THE REACTION OF AIRWAYS SMOOTH MUSCULATURE IN THE NEWBORN WITH MECONIUM ASPIRATION SYNDROME (MAS)

机译:在胎粪吸入综合征(MAS)中胎粪中胎粪中平滑肌反应中的金属元素的作用

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摘要

The role of meconium in the respiratory system was studied in newborns, who died from various causes (250 up to 3000 g of weight). We monitored tracheal rings response to dopamine, serotonin and ethanol in different concentrations (dopamine: 0,05 mg/ml, 0,5 mg/ml, 5 mg/ml; serotonin (5-HT): 10-4, 10-3, 10-2, 10-1 mol/dm3; ethanol: 0,02 ml, 0,5 ml, 1,0 ml; 96%). Tracheal smooth musculature tonus (TSM) was examined in 48 tracheal preparations taken after the newborn exitus due to different reasons. Based on functional researche of isolated preparations of tracheas, it may be concluded that: aspiration of me-conium has not changed the response of TSM to dopamine, serotonin and ethanol (p>0,1) in comparison with the control group, which have died due to different lung inflammatory processes (e.g. pneumonia, bronchopneumonia, atelectasis, cerebral hemorrhage). The results suggest that meconium does not potentiate the constricting action of dopamine, serotonin and ethanol in tracheobronchial system. Meconium causes mild relaxation of the TSM through a mechanism that is not intermediated by the products of cyclooxygenases (prostaglandins, prostacyclins) from the tracheal epithelium or proteins. Also, as it seems, the direct activity of many tested acids in the smooth musculature has no significant impact on increase of the airways tonus in MAS syndrome.
机译:研究了胎粪在呼吸系统中的作用,这些新生儿死于各种原因(250至3000 g体重)。我们监测了气管环对不同浓度的多巴胺,5-羟色胺和乙醇的反应(多巴胺:0.05 mg / ml,0.5 mg / ml,5 mg / ml; 5-羟色胺(5-HT):10-4、10-3 ,10-2、10-1 mol / dm 3 ;乙醇:0.02毫升,0.5毫升,1.0毫升; 96%)。由于不同的原因,在新生儿出院后采取的48支气管制剂中检查了气管平滑肌肌张力(TSM)。根据气管分离制剂的功能研究,可以得出以下结论:与对照组相比,中等水平的吸取粪便并没有改变TSM对多巴胺,5-羟色胺和乙醇的反应(p> 0,1)。因不同的肺部炎症过程而死亡(例如肺炎,支气管肺炎,肺不张,脑出血)。结果表明,胎粪不能增强气管支气管系统中多巴胺,5-羟色胺和乙醇的收缩作用。胎粪通过不受气管上皮或蛋白质中的环氧合酶(前列腺素,前列腺环素)产物介导的机制引起TSM的轻度松弛。而且,看起来,许多测试酸在平滑肌肉组织中的直接活性对MAS综合征气道通气的增加没有显着影响。

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