首页> 美国卫生研究院文献>BMJ Open >REpeated AutoLogous Infusions of STem cells In Cirrhosis (REALISTIC): a multicentre phase II open-label randomised controlled trial of repeated autologous infusions of granulocyte colony-stimulating factor (GCSF) mobilised CD133+ bone marrow stem cells in patients with cirrhosis. A study protocol for a randomised controlled trial

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REpeated AutoLogous Infusions of STem cells In Cirrhosis (REALISTIC): a multicentre phase II open-label randomised controlled trial of repeated autologous infusions of granulocyte colony-stimulating factor (GCSF) mobilised CD133+ bone marrow stem cells in patients with cirrhosis. A study protocol for a randomised controlled trial

机译：肝硬化中STem细胞的自体重复输注（REALISTIC）：一项多中心II期开放标签随机对照试验多次自体输注粒细胞集落刺激因子（GCSF）动员了CD133 +骨髓干细胞。随机对照试验的研究方案

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IntroductionLiver disease mortality and morbidity are rapidly rising and liver transplantation is limited by organ availability. Small scale human studies have shown that stem cell therapy is safe and feasible and has suggested clinical benefit. No published studies have yet examined the effect of stem cell therapy in a randomised controlled trial and evaluated the effect of repeated therapy.

机译：简介肝脏疾病的死亡率和发病率正在迅速上升，肝脏移植受到器官可用性的限制。人体的小规模研究表明，干细胞治疗是安全可行的，并已表明其临床益处。尚无发表的研究在随机对照试验中检查干细胞治疗的效果并评估重复治疗的效果。

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期刊名称 BMJ Open
作者
A King; D Barton; H A Beard; N Than; J Moore; C Corbett; J Thomas; K Guo; I Guha; D Hollyman; D Stocken; C Yap; R Fox; S J Forbes; P N Newsome;
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年(卷),期 2015(5),3
年度 2015
页码 e007700
总页数 10
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1. REpeated AutoLogous Infusions of STem cells In Cirrhosis (REALISTIC): a multicentre, phase II, open-label, randomised controlled trial of repeated autologous infusions of granulocyte colony-stimulating factor (GCSF) mobilised CD133+ bone marrow stem cells in patients with cirrhosis. A study protocol for a randomised controlled trial [J] . A King, C Corbett, C Yap, BMJ Open . 2015,第3期

机译：肝硬化中STem细胞的自体重复输注（REALISTIC）：一项多中心，II期，开放标签，随机对照试验，多次自体输注粒细胞集落刺激因子（GCSF）动员了肝硬化患者的CD133 +骨髓干细胞。随机对照试验的研究方案
2. REpeated AutoLogous Infusions of STem cells In Cirrhosis (REALISTIC): a multicentre, phase II, open-label, randomised controlled trial of repeated autologous infusions of granulocyte colony-stimulating factor (GCSF) mobilised CD133+ bone marrow stem cells in patients with cirrhosis. A study protocol for a randomised controlled trial [J] . A King, C Corbett, C Yap, BMJ Open . 2015,第3期

机译：肝硬化中STem细胞的自体重复输注（REALISTIC）：一项多中心，II期，开放标签，随机对照试验，多次自体输注粒细胞集落刺激因子（GCSF）动员了肝硬化患者的CD133 +骨髓干细胞。随机对照试验的研究方案
3. Research on advanced intervention using novel bone marrOW stem cell (RAINBOW): a study protocol for a phase I, open-label, uncontrolled, dose-response trial of autologous bone marrow stromal cell transplantation in patients with acute ischemic stroke [J] . Hideo Shichinohe, Masahito Kawabori, Hiroaki Iijima, BMC Neurology . 2017,第1期

机译：使用新型骨marrOW干细胞（RAINBOW）进行高级干预的研究：一项针对急性缺血性中风患者自体骨髓基质细胞移植的I期，开放标签，不受控制，剂量反应试验的研究方案
4. Phase 1 Trial of Retroviral-Mediated Transfer of the Human MDR-1 In Patients Undergoing High-Dose Chemotherapy and Autologous Stem Cell Transplantation [C] . Charles Hesdorffer, Janet Ayello, Maureen Ward, Keio International Symposium for Life Sciences and Medicine . 2000

机译：逆转录病毒介导的人MDR-1转移的第1期试验在接受高剂量化疗和自体干细胞移植的患者中
5. Granulocyte colony-stimulating factor and autologous CD133-positive stem-cell therapy in liver cirrhosis (REALISTIC): an open-label randomised controlled phase 2 trial [O] . Philip Noel Newsome, Richard Fox, Andrew L King, -1

机译：肝硬化中粒细胞集落刺激因子和自体CD133阳性干细胞疗法（REALISTIC）：一项开放标签随机对照的2期试验
6. REpeated AutoLogous Infusions of STem cells In Cirrhosis (REALISTIC):a multicentre, phase II, open-label, randomised controlled trial of repeated autologous infusions of granulocyte colony-stimulating factor (GCSF) mobilised CD133+ bone marrow stem cells in patients with cirrhosis. A study protocol for a randomised controlled trial [O] . King, A, Barton, D, Beard, H A, 2015

机译：重复自体输注sTem细胞在肝硬化（REaLIsTIC）：一项多中心，II期，开放标签，随机对照试验，重复自体输注粒细胞集落刺激因子（GCsF）动员肝硬化患者CD133 +骨髓干细胞。一项随机对照试验的研究方案

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