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首页> 美国卫生研究院文献>The Journal of Physiology >Regulation of bradykinin-induced activation of volume-sensitive outwardly rectifying anion channels by Ca2+ nanodomains in mouse astrocytes
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Regulation of bradykinin-induced activation of volume-sensitive outwardly rectifying anion channels by Ca2+ nanodomains in mouse astrocytes

机译：Ca2 +纳米域在小鼠星形胶质细胞中对缓激肽诱导的体积敏感的向外整流阴离子通道活化的调节

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Non-technical summaryCell volume regulation is an essential function involved not only in homeostasis, but also in cell migration, fission and programmed cell death. The volume-sensitive outwardly rectifying (VSOR) anion channel provides the main pathway for anion transport across the cell membrane during the regulation. We previously demonstrated that an inflammatory mediator, bradykinin, activates the VSOR channels in the major glial cells, astrocytes, in the brain derived from mice and the channels send signals to adjacent neurons through the release of glutamate. Here we demonstrate that this activation is controlled in the immediate vicinity of Ca2+-permeable channel proteins in the astrocytes via high concentrations of intracellular Ca2+, so-called ‘Ca2+ nanodomains’. This mechanism would provide a basis for responding quickly and certainly to even a minute amount of bradykinin released from surrounding tissues (e.g. slightly damaged blood vessel walls) with local control of cell shape changes and signal transmission by astrocytes.
机译：非技术总结细胞体积调节不仅是体内稳态的重要功能，而且还参与细胞迁移，裂变和程序性细胞死亡。体积敏感的向外整流（VSOR）阴离子通道为调节过程中阴离子跨细胞膜的运输提供了主要途径。我们先前证明，炎症介质缓激肽激活小鼠大脑中主要胶质细胞星形胶质细胞中的VSOR通道，并且该通道通过释放谷氨酸将信号发送至邻近的神经元。在这里，我们证明了这种激活是通过高浓度的细胞内Ca 2 + 在星形胶质细胞中Ca 2 + 渗透通道蛋白的紧邻区域控制的，即所谓的“ Ca 2 + 纳米域。这种机制将为通过局部控制细胞形状变化和星形胶质细胞的信号传递而迅速肯定地对周围组织释放的缓激肽作出反应提供基础（例如，血管壁受到轻微损伤）。

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