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首页> 美国卫生研究院文献>BMJ Case Reports >Unexpected outcome (positive or negative) including adverse drug reactions: The use of fetal fibronectin testing in the management of a triplet pregnancy with a short cervix
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Unexpected outcome (positive or negative) including adverse drug reactions: The use of fetal fibronectin testing in the management of a triplet pregnancy with a short cervix

机译：意外结果（阳性或阴性）包括药物不良反应：胎儿纤连蛋白检测在子宫颈短的三联体妊娠治疗中的应用

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Following in vitro fertilisation treatment, a 40-year-old woman was expecting trichorionic, triamniotic triplets. Her cervix shortened from 34 mm at 16+5 weeks to 16 mm at 20+5 weeks, a risk reported with 100% delivery before 28 weeks gestation. She was admitted to hospital and at 24+1 weeks was given corticosteroids. From 21+5 weeks her cervical length remained below 16 mm. However, weekly fetal fibronectin (fFN) tests were negative from 22+5 weeks to delivery at 35+5 weeks. This, along with an absence of symptoms, gave her doctors confidence to manage her as an outpatient from 28 weeks. At 33+5 weeks she was diagnosed as having pre-eclampsia and three live births were delivered by prelabour caesarean section. Prior to delivery her cervical length was 10 mm and fFN test remained negative. There are no reports of outcome following a negative fFN with a short cervix in triplet pregnancies but fFN could be a useful tool, in conjunction with cervical length measurement, in the management of triplets.
机译：在进行体外受精治疗后，一名40岁妇女正期待三甲膜三联症。她的子宫颈长度从16 +5 周的34毫米缩短到20 +5 周的16毫米，据报道有风险在妊娠28周前分娩100％。她入院，并在24 +1 周接受了糖皮质激素治疗。从21 +5 周开始，她的宫颈长度一直保持在16毫米以下。然而，从22 +5 周到35 +5 周分娩，每周胎儿纤连蛋白（fFN）测试均为阴性。这加上没有症状，使她的医生有信心从28周起将她作为门诊病人进行治疗。在33 +5 周时，她被诊断患有先兆子痫，并通过剖腹产前剖腹产分娩了3例活产。分娩前她的宫颈长度为10毫米，fFN试验仍为阴性。在三胞胎妊娠中，fFN阴性且子宫颈短，fFN阴性后无结局的报道，但fFN结合宫颈长度测量可用于三联症的治疗。

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