首页> 美国卫生研究院文献>BMC Veterinary Research >Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks

【2h】

Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks

机译：赛拉沙星对番鸭鸭致病性大肠杆菌的药代动力学和药效学模拟

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

BackgroundThis study focused on utilizing pharmacokinetics/pharmacodynamics (PK/PD) modeling to optimize therapeutic dosage regimens of sarafloxacin against avian pathogenic Escherichia. coli O78 strain in Muscovy ducks. The ex vivo PK/PD study of sarafloxacin was conducted in Muscovy ducks after intravenous (i.v.) and oral (p.o.) administrations at a single dose of 10 mg/kg bodyweight (BW). The serum samples were analyzed by reverse phase high-performance liquid chromatography (RP-HPLC) using a fluorescence detection method. Sarafloxacin PK data were analyzed by a non-compartmental method using Winnonlin software.

机译：背景这项研究的重点是利用药代动力学/药效学（PK / PD）模型来优化赛拉沙星抗禽致病性大肠杆菌的治疗剂量方案。番鸭中的大肠杆菌O78菌株。在以静脉内（i.v.）和口服（p.o.）施用10 mg / kg体重（BW）的单剂量后，在番鸭中进行了赛拉沙星的离体PK / PD研究。使用荧光检测方法，通过反相高效液相色谱法（RP-HPLC）分析血清样品。使用Winnonlin软件通过非房室方法分析了Sarafloxacin PK数据。

著录项

期刊名称 BMC Veterinary Research
作者
Yang Yu; Yu Feng Zhou; Jian Sun; Wei Shi; Xiao Ping Liao; Ya Hong Liu;
展开▼
作者单位

展开▼
年(卷),期 2016(13),-1
年度 2016
页码 47
总页数 8
原文格式 PDF
正文语种
中图分类动物医学（兽医学）;
关键词
Dosage regimens Muscovy ducks Mutant prevention concentration Pharmacokinetics/pharmacodynamics Sarafloxacin Avian pathogenic Escherichia Coli;

机译：剂量方案;番鸭;突变预防浓度;药代动力学/药效学;沙拉沙星;禽致病性大肠杆菌;

相似文献

外文文献
中文文献
专利

1. Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks [J] . Yang Yu, Yu Feng Zhou, Jian Sun, BMC Veterinary Research . 2017,第1期

机译：赛拉沙星对番鸭鸭致病性大肠杆菌的药代动力学和药效学模拟
2. Comparison of in vitro activities and pharmacokinetics/pharmacodynamics estimations of veterinary fluoroquinolones against avian pathogenic Escherichia coli isolates. [J] . Ozawa M, Baba K, Shimizu Y, Microbial drug resistance: MDR : Mechanisms, epidemiology, and disease . 2010,第4期

机译：兽用氟喹诺酮类药物对禽类致病性大肠杆菌分离株的体外活性和药代动力学/药效学估计值的比较。
3. Duck viral infection escalated the incidence of avian pathogenic i >Escherichia coli/i>Escherichia coli in China [J] . Liu Chengyu, Diao Youjiang, Wang Dongxue, Transboundary and emerging diseases . 2019,第2期

机译：鸭病毒感染升级了禽病原＆lt中的发病率。中国大肠杆菌的大肠杆菌
4. BIOSECURITY RISK FACTORS FOR HIGHLY PATHOGENIC AVIAN INFLUENZA(H5N8) VIRUS INFECTION IN DUCK FARMS, FRANCE [C] . Meeting of The Society^for^Veterinary^Epidemiology^and^Preventive^Medicine^(Great^Britain). . 2020

机译：法国鸭农场高病禽流感（H5N8）病毒感染的生物安全风险因素
5. Whole transcriptome response of chicken spleen and peripheral blood leukocytes to avian pathogenic Escherichia coli [D] . Sandford, Erin Elizabeth 2011

机译：鸡脾脏和外周血白细胞对鸟类致病性大肠杆菌的全转录组反应
6. Comparative Characteristics and Zoonotic Potential of Avian Pathogenic Escherichia coli (APEC) Isolates from Chicken and Duck in South Korea [O] . Jiyeon Jeong, Ji-Youn Lee, Min-Su Kang, 2021

机译：韩国鸡和鸭禽病原大肠杆菌（APEC）分离株的比较特征和动物势
7. Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic in Muscovy ducks [O] . 2017

机译：赛拉沙星对番鸭鸭致病性的药代动力学和药效学模拟

Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks

摘要

著录项

相似文献

相关主题

期刊订阅