...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BMC Veterinary Research >Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks
【24h】

Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks

机译：赛拉沙星对番鸭鸭致病性大肠杆菌的药代动力学和药效学模拟

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background This study focused on utilizing pharmacokinetics/pharmacodynamics (PK/PD) modeling to optimize therapeutic dosage regimens of sarafloxacin against avian pathogenic Escherichia. coli O78 strain in Muscovy ducks. The ex vivo PK/PD study of sarafloxacin was conducted in Muscovy ducks after intravenous (i.v.) and oral (p.o.) administrations at a single dose of 10?mg/kg bodyweight (BW). The serum samples were analyzed by reverse phase high-performance liquid chromatography (RP-HPLC) using a fluorescence detection method. Sarafloxacin PK data were analyzed by a non-compartmental method using Winnonlin software. Results Calculations of the area under the concentration-time curves (AUC0-24h) were 8.57?±?0.59 and 8.37?±?0.29?μg?·?h/ml following i.v. and p.o. administration, respectively. Elimination half-lives ( t 1/2 β) were 6.11?±?0.99?h and 8.21?±?0.64?h for i.v. injection and p.o. administration, respectively. The mean in vitro plasma protein binding of sarafloxacin was 39.3%. Integration using the sigmoid E max model, the mean values of AUC0-24h/MIC needed for bacteriostatic, bactericidal and bacterial eradication action were 25.4, 40.6, and 94.4?h, respectively. Conclusions Sarafloxacin administered at a 10?mg/kg dose may be insufficient for treatment of E. coli O78 infections with an MIC equally to or over 0.125?μg/ml. Furthermore, higher doses of sarafloxacin are required to minimize antimicrobial resistance considering the MPC theory.
机译：背景技术这项研究的重点是利用药代动力学/药效学（PK / PD）模型来优化沙拉沙星抗禽致病性大肠杆菌的治疗剂量方案。番鸭中的大肠杆菌O78菌株。静脉注射（i.v.）和口服（p.o.）单剂量10？mg / kg体重（BW）后，在番鸭中进行了赛拉沙星的体外PK / PD研究。使用荧光检测方法，通过反相高效液相色谱法（RP-HPLC）分析血清样品。使用Winnonlin软件通过非房室方法对Sarafloxacin PK数据进行了分析。结果静脉注射后，浓度-时间曲线下面积（AUC 0-24h ）的计算为8.57±0.59和8.37±0.29μg··h / ml。和p.o.行政管理。 i.v.的消除半衰期（t 1/2β）为6.11？±？0.99？h和8.21？±？0.64？h。注射和邮政行政管理。 sarafloxacin的平均体外血浆蛋白结合率为39.3％。使用S型E max 模型进行积分，抑菌，杀菌和除菌作用所需的AUC 0-24h / MIC的平均值分别为25.4、40.6和94.4？h ， 分别。结论以10？mg / kg的剂量服用沙拉沙星可能不足以治疗MIC等于或超过0.125？g / ml的大肠杆菌O78感染。此外，考虑到MPC理论，需要更高剂量的沙拉沙星才能使抗菌药耐药性降至最低。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号