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首页> 美国卫生研究院文献>Journal of the Royal Society Interface >Biocompatibility degradability bioactivity and osteogenesis of mesoporous/macroporous scaffolds of mesoporous diopside/poly(l-lactide) composite
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Biocompatibility degradability bioactivity and osteogenesis of mesoporous/macroporous scaffolds of mesoporous diopside/poly(l-lactide) composite

机译：介孔透辉石/聚（丙交酯）复合材料的介孔/大孔支架的生物相容性降解性生物活性和成骨作用

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摘要

Bioactive mesoporous diopside (m-DP) and poly(l-lactide) (PLLA) composite scaffolds with mesoporous/macroporous structure were prepared by the solution-casting and particulate-leaching method. The results demonstrated that the degradability and bioactivity of the mesoporous/macroporous scaffolds were significantly improved by incorporating m-DP into PLLA, and that the improvement was m-DP content-dependent. In addition, the scaffolds containing m-DP showed the ability to neutralize acidic degradation products and prevent the pH from dropping in the solution during the soaking period. Moreover, the scaffolds containing m-DP enhanced attachment, proliferation and alkaline phosphatase activity of MC3T3-E1 cells, which were also m-DP content-dependent. Furthermore, the histological and immunohistochemical analysis results showed that the scaffolds with m-DP significantly promoted new bone formation and improved the materials degraded in vivo, indicating good biocompatibility. The results suggested that the mesoporous/macroporous scaffolds of the m-DP/PLLA composite with osteogenesis had a potential for bone regeneration.
机译：通过溶液浇铸和颗粒浸出法制备了具有介孔/大孔结构的生物活性介孔透辉石（m-DP）和聚（l-丙交酯）（PLLA）复合支架。结果表明，通过将m-DP掺入PLLA中，中孔/大型支架的可降解性和生物活性得到了显着改善，并且该改善是m-DP含量依赖性的。另外，含有m-DP的支架显示出中和酸性降解产物的能力，并防止了在浸泡期间溶液中pH值的下降。此外，含有m-DP的支架可增强MC3T3-E1细胞的附着，增殖和碱性磷酸酶活性，而MC3T3-E1细胞也具有m-DP含量依赖性。此外，组织学和免疫组织化学分析结果表明，具有m-DP的支架显着促进了新骨的形成并改善了体内降解的材料，表明具有良好的生物相容性。结果表明，具有成骨作用的m-DP / PLLA复合材料的介孔/大孔支架具有骨再生的潜力。

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