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Ocular perfusion pressure and color Doppler imaging of the external ophthalmic artery of rabbits treated with sildenafil citrate

机译:枸sil酸西地那非治疗兔眼外动脉的眼压和彩色多普勒成像

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摘要

BackgroundIt has been proposed that sildenafil citrate can increase ocular blood flow, and that this property can be used to treat ocular disorders that involve reflex vasoconstriction. This study therefore proposes to ascertain the vasodilator effect of the drug on retrobulbar circulation in healthy rabbits. For this matter rabbits treated with sildenafil citrate or saline solution had their intraocular pressure (IOP), mean arterial pressure (MAP), ocular perfusion pressure (OPP) and color Doppler imaging of the external ophthalmic artery measured prior to treatment and on days one (moment M1), seven (when M2), fourteen (moment M3), twenty-one (moment M4), and thirty (moment M5) of treatment.
机译:背景技术已经提出柠檬酸西地那非可以增加眼部血流,并且该性质可以用于治疗涉及反射性血管收缩的眼部疾病。因此,本研究建议确定该药物对健康兔球后循环的血管舒张作用。为此,在治疗前和治疗后第1天测量兔子的柠檬酸西地那非或盐水溶液的眼压(IOP),平均动脉压(MAP),眼灌注压(OPP)和彩色多普勒成像。 M1时刻),七个(M2时刻),十四个(时刻M3),二十一个(时刻M4)和三十个(时刻M5)治疗。

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