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首页> 外文学位 >Diurnal variation of intraocular pressure, mean ocular perfusion pressure, optic nerve head topography and capillary blood flow in untreated early primary open angle glaucoma.
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Diurnal variation of intraocular pressure, mean ocular perfusion pressure, optic nerve head topography and capillary blood flow in untreated early primary open angle glaucoma.

机译：未经治疗的早期原发性开角型青光眼的眼内压，平均眼压，眼神经头地形图和毛细血管血流量的昼夜变化。

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摘要

Purpose. To investigate diurnal change and pattern of variation in intraocular pressure (IOP), blood pressure (SBP, DBP), optic nerve head (ONH) topography and capillary blood flow (BF) in untreated early primary open angle glaucoma (uPOAG) and healthy volunteers.; Methods. IOP, SBP, DBP and ONH topography (using the HRT II) were measured every hour and ONH BF was measured every two hours in 14 patients (age 56.3, SD 12, 7 men) with uPOAG and 14 normals (age 57.6, SD 9.9, 5 men), on a single day between 7 AM and 10 PM. The Mean Ocular Perfusion Pressure (MOPP) was calculated. Mixed effect linear models were used to analyse the repeated measures data in which both fixed and random effects were included.; Results. The uPOAG group had the higher IOP (p 0.001) and tower MOPP (p = 0.025). There was a significant diurnal change in IOP, SBP, DBP, and MOPP in both groups (p 0.001). The pattern of diurnal variation in IOP (p = 0.137), SBP (p = 0.569) and DBP (p = 0.937) was not significantly different between groups but was significantly different for MOPP (p = 0.040). Relative change in MOPP was larger in uPOAG (38% vs. 26%, p 0.001) but was similar for IOP (42% vs. 41%, p = 0.786). There was a significant effect of DBP on IOP over the course of the day in uPOAG (p = 0.011) but not in normals (p = 0.733). Local Flow (LF) measured at the sector of most topography fluctuation (MTF) significantly changed in uPOAG (p = .006) but not in normals (p = 0.660). SBP had a significant effect on LF over the course of the day in uPOAG (p = 0.043). Temporal and temporal-inferior cup volume (CV), rim volume (RV) and cup shape measure (CSM) were significantly different between uPOAG and normals (p 0.030). The temporal and temporal-inferior CV (p 0.003) and reference height (RH) (p 0.001) had a significant diurnal change in uPOAG and there was a significant association between RH and CV over the course of the day (p 0.016). RH was significantly associated with change in MOPP in uPOAG (p = 0.002) but not in normals (p = 0.232). In normals, the RV in temporal, temporal-inferior and temporal-superior sectors significantly changed during the day (p 0.016); Conclusion. Relative diurnal change in IOP was similar for both uPOAG and normals but MOPP showed significant differences. (Abstract shortened by UMI.)
机译：目的。研究未经治疗的早期原发性开角型青光眼（uPOAG）和健康志愿者的眼压（IOP），血压（SBP，DBP），视神经头（ONH）地形和毛细血管血流量（BF）的昼夜变化和变化模式。;方法。每小时测量uPOAG的14例患者（56.3岁，SD 12，7名男性）和14例正常人群（57.6岁，SD 9.9岁）的IOP，SBP，DBP和ONH地形（使用HRT II），每2小时测量ONH BF （5位男士）在一天的早上7点至晚上10点之间进行操作。计算平均眼压（MOPP）。混合效应线性模型用于分析重复措施数据，其中包括固定效应和随机效应。结果。 uPOAG组的IOP（p <0.001）和塔MOPP（p = 0.025）较高。两组的IOP，SBP，DBP和MOPP均有明显的昼夜变化（p <0.001）。两组间IOP（p = 0.137），SBP（p = 0.569）和DBP（p = 0.937）的昼夜变化规律无显着差异，但MOPP的昼夜变化显着不同（p = 0.040）。 uPOAG中MOPP的相对变化较大（38％对26％，p <0.001），但IOP相似（42％对41％，p = 0.786）。在一天中，在uPOAG中，DBP对IOP有显着影响（p = 0.011），而在正常人中则没有（p = 0.733）。在uPOAG中，在最大地形波动（MTF）扇区处测得的局部流量（LF）发生了显着变化（p = .006），而在法线中则没有变化（p = 0.660）。在一天中，在uPOAG中，SBP对LF有显着影响（p = 0.043）。 uPOAG与正常人之间的时间和颞下杯体积（CV），轮辋体积（RV）和杯形度量（CSM）显着不同（p <0.030）。颞和颞下CV（p <0.003）和参考身高（RH）（p <0.001）在uPOAG中有明显的昼夜变化，并且在一天当中，RH和CV之间存在显着相关性（p <0.016） ）。 RH与uPOAG中MOPP的变化显着相关（p = 0.002），而在正常人中则无相关性（p = 0.232）。在正常情况下，白天，颞下和颞上部门的RV在白天有显着变化（p <0.016）。结论。 uPOAG和正常人的IOP相对昼夜变化相似，但MOPP显示出显着差异。 （摘要由UMI缩短。）

著录项

  • 作者

    Sehi, Mitra.;

  • 作者单位

    University of Waterloo (Canada).;

  • 授予单位 University of Waterloo (Canada).;
  • 学科 Health Sciences Ophthalmology.
  • 学位 Ph.D.
  • 年度 2005
  • 页码 235 p.
  • 总页数 235
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 R770.1;
  • 关键词

  • 入库时间 2022-08-17 11:41:33

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