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Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney

机译：环氧合酶（COX）-1和COX-2抑制对健康猫肾脏中呋塞米诱导的肾脏反应和亚型免疫定位的影响

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摘要

BackgroundThe role of cyclooxygenase(COX)-1 and COX-2 in the saluretic and renin-angiotensin responses to loop diuretics in the cat is unknown. We propose in vivo characterisation of isoform roles in a furosemide model by administering non-steroidal anti-inflammatory drugs (NSAIDs) with differing selectivity profiles: robenacoxib (COX-2 selective) and ketoprofen (COX-1 selective).

机译：背景环氧合酶（COX）-1和COX-2在猫的利尿剂和肾素-血管紧张素对loop利尿剂的反应中的作用尚不清楚。我们建议通过施用具有不同选择性特征的非甾体抗炎药（NSAIDs）来表征呋塞米模型中同种型角色的体内作用：罗贝纳昔布（COX-2选择性）和酮洛芬（COX-1选择性）。

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期刊名称 BMC Veterinary Research
作者
L. Pelligand; N. Suemanotham; J. N. King; W. Seewald; H. Syme; K. Smith; P. Lees; J. Elliott;
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作者单位

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年(卷),期 2015(11),-1
年度 2015
页码 296
总页数 11
原文格式 PDF
正文语种
中图分类动物医学（兽医学）;
关键词
Furosemide Cyclooxygenase COXib NSAIDs Robenacoxib Ketoprofen Feline Renal Macula densa Renin-angiotensin-aldosterone system;

机译：速尿;环氧合酶;COXib;NSAID;罗贝奈昔;酮洛芬;猫;肾;黄斑;肾素-血管紧张素-醛固酮系统;

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专利

1. Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney [J] . L. Pelligand, N. Suemanotham, J. N. King, BMC Veterinary Research . 2015,第1期

机译：环氧合酶（COX）-1和COX-2抑制对健康猫肾中呋塞米诱导的肾脏反应和亚型免疫定位的影响
2. Cyclooxygenase-2 (COX-2) inhibition limits abnormal COX-2 expression and progressive injury in the remnant kidney [J] . CLARICE KAZUE FUJIHARA, GLáUCIA RUTIGLIANO ANTUNES, ANA LúCIA MATTAR, Kidney international. . 2003,第6期

机译：环氧合酶2（COX-2）的抑制作用限制了残余肾脏中COX-2的异常表达和进行性损伤
3. Differential effects of inhibition of isoforms of cyclooxygenase (COX-1, COX-2) in chronic inflammation (see comments) [J] . Gilroy DW, Tomlinson A, Willoughby DA Inflammation research: Official journal of the European Histamine Research Society . 1998,第2期

机译：抑制环氧合酶同工型（COX-1，COX-2）在慢性炎症中的差异作用（参见评论）
4. Expression of Cyclooxygenase (COX)-2 in Human Endometrial Adenocarcinoma Cell Line HEC-1B:An In Vitro Model of the Expression of COX-2 by Platelet-Activating Factor [C] . KOHJI MlYAZAKI, KOHJI FUKUNAGA, IQBAL MUNIR, International Symposium on the Cell and Molecular Biology of Endometrial Carcinoma . 2003

机译：环氧氧酶（COX）-2在人子宫内膜腺癌细胞系HEC-1B中的表达：血小板活化因子COX-2表达的体外模型
5. Selective cyclooxygenase-2 (COX-2) inhibition and risk of acute myocardial infarction or stroke in a population of rheumatoid arthritis and osteoarthritis patients from an administrative medical claims dataset. [D] . Spalding, William Michael. 2003

机译：来自行政医疗索赔数据集的类风湿关节炎和骨关节炎患者群体中的选择性环氧合酶2（COX-2）抑制和急性心肌梗塞或中风的风险。
6. Cyclooxygenase in normal human tissues – is COX-1 really a constitutive isoform and COX-2 an inducible isoform? [O] . Nina Zidar, Katarina Odar, Damjan Glavač, 2009

机译：正常人体组织中的环氧合酶– COX-1真的是组成型同工型而COX-2是诱导型同工型吗？
7. Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney [O] . 2015

机译：环氧合酶（COX）-1和COX-2抑制对健康猫肾脏中呋塞米诱导的肾脏反应和亚型免疫定位的影响

Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney

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