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Increased whole blood FFA2/GPR43 receptor expression is associated with increased 30-day survival in patients with sepsis

机译：全血FFA2 / GPR43受体表达增加与败血症患者30天生存期增加相关

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摘要

ObjectiveSepsis is a condition associated with a dysregulated inflammatory response to infection with significant morbidity. Recent advances have elucidated the vital role that the short chain fatty acid glycoprotein receptor 43 (FFA2/GPR43) plays in inflammatory and immunomodulatory pathways. We hypothesized that elevated whole blood GPR43 RNA expression would be associated with increased 30-day survival in patients admitted with sepsis. Patients (n = 93) admitted to the intensive care unit with the diagnosis of sepsis underwent quantitative real time PCR within 48 h of intensive care unit admission. Clinical and demographical parameters were retrospectively extracted from the chart and compared to quantitative measurements of GPR43 RNA expression.

机译：ObjectiveSepsis是一种与感染相关的炎症反应失调的疾病，发病率很高。最近的进展阐明了短链脂肪酸糖蛋白受体43（FFA2 / GPR43）在炎症和免疫调节途径中的重要作用。我们假设败血症患者的全血GPR43 RNA表达升高与30天生存期增加有关。重症监护病房入院的患者（n = 93）被诊断为败血症，在入院48小时内进行了定量实时PCR。从图表中回顾性提取临床和人口统计学参数，并将其与GPR43 RNA表达的定量测量结果进行比较。

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期刊名称 BMC Research Notes
作者
Zyad J. Carr; Andry Van De Louw; Graham Fehr; Jialiu D. Li; Allen Kunselman; Victor Ruiz-Velasco;
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作者单位

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年(卷),期 2018(11),-1
年度 2018
页码 41
总页数 7
原文格式 PDF
正文语种
中图分类
关键词
GPR43 FFA2 Sepsis Short-chain fatty acids Multiple organ dysfunction;

机译：GPR43;FFA2;败血症;短链脂肪酸;多器官功能障碍;

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专利

1. Increased whole blood FFA2/GPR43 receptor expression is associated with increased 30-day survival in patients with sepsis [J] . Zyad J. Carr, Andry Van De Louw, Graham Fehr, BMC research notes . 2018,第1期

机译：脓毒症患者全血FFA2 / GPR43受体表达增加与30天生存期增加相关
2. Circulating lncRNA ITSN1‐2 is upregulated, and its high expression correlates with increased disease severity, elevated inflammation, and poor survival in sepsis patients [J] . Qingwei Zeng, Jingdong Wu, Shijiang Yang Journal of clinical laboratory analysis. . 2019,第4期

机译：循环中的lncRNA ITSN1-2上调，其高表达与脓毒症患者疾病的严重程度增加，炎症增加和生存率低有关
3. Circulating lncRNA ITSN1‐2 is upregulated, and its high expression correlates with increased disease severity, elevated inflammation, and poor survival in sepsis patients [J] . Zeng Qingwei, Wu Jingdong, Yang Shijiang Journal of clinical laboratory analysis. . 2019,第4期

机译：循环LNCRNA itn1-2是上调的，其高表达与疾病严重程度增加，炎症升高，败血症患者的存活率较差相关
4. Increased Expression of Toll-Like Receptor (TLR)4 in the Nasal Mucosa and Peripheral Blood of Children: Role In Protection Against Allergic Inflammation [C] . M.K. Tulic, P. Fiset, H. Zheng Asia Pacific Congress of Allergology and Clinical Immunology . 2004

机译：在鼻粘膜和儿童周围血液中增加了Toll样受体（TLR）4的表达：在过敏性炎症的保护中的作用
5. Overexpression of the receptor tyrosine kinase EphA2 induces malignant transformation of benign mammary epithelia: Implication for increased cell survival and altered cellular adhesions in breast cancer. [D] . Zelinski, Daniel Paul. 2001

机译：受体酪氨酸激酶EphA2的过表达诱导了良性乳腺上皮的恶性转化：暗示增加细胞存活率和改变乳腺癌细胞粘附。
6. Early identification of sepsis in hospital inpatients by ward nurses increases 30-day survival [O] . Malvin Torsvik, Lise Tuset Gustad, Arne Mehl, 2016

机译：病房护士尽早发现住院病人败血症可增加30天生存率
7. Increased whole blood FFA2/GPR43 receptor expression is associated with increased 30-day survival in patients with sepsis [O] . Zyad J. Carr, Andry Van De Louw, Graham Fehr, 2018

机译：增加全血FFA2 / GPR43受体表达与败血症患者的30天存活增加有关

Increased whole blood FFA2/GPR43 receptor expression is associated with increased 30-day survival in patients with sepsis

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