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Toward the identification of causal genes in complex diseases: a gene-centric joint test of significance combining genomic and transcriptomic data

机译：鉴定复杂疾病中的致病基因：以基因为中心的联合检验结合基因组和转录组数据进行显着性检验

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摘要

BackgroundGene identification using linkage, association, or genome-wide expression is often underpowered. We propose that formal combination of information from multiple gene-identification approaches may lead to the identification of novel loci that are missed when only one form of information is available.

机译：背景技术使用连锁，缔合或全基因组表达的基因鉴定通常功能不足。我们建议，来自多种基因鉴定方法的信息的正式组合可能会导致只有一种形式的信息可用时，才会遗漏新基因座的鉴定。

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期刊名称 BMC Proceedings
作者
Jac C Charlesworth; Juan M Peralta; Eugene Drigalenko; Harald HH Göring; Laura Almasy; Thomas D Dyer; John Blangero;
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年(卷),期 2009(3),Suppl 7
年度 2009
页码 S92
总页数 5
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1. The use of the twin model to investigate the genetics and epigenetics of skin diseases with genomic, transcriptomic and methylation data [J] . BatailleV., LensM., SpectorT.D. Journal of the European Academy of Dermatology and Venereology: JEADV . 2012,第9期

机译：使用孪生模型通过基因组，转录组和甲基化数据研究皮肤疾病的遗传学和表观遗传学
2. Significance analysis of time-series transcriptomic data: A methodology that enables the identification and further exploration of the differentially expressed genes at each time-point [J] . Dutta B, Snyder R, Klapa MI Biotechnology and Bioengineering . 2007,第3期

机译：时间序列转录组数据的意义分析：一种方法，可以在每个时间点识别和进一步探索差异表达的基因
3. A novel joint analysis framework improves identification of differentially expressed genes in cross disease transcriptomic analysis [J] . Wenyi Qin, Hui Lu BioData Mining . 2018,第1期

机译：一种新颖的联合分析框架可改善跨疾病转录组分析中差异表达基因的鉴定
4. Identification of Genes for Complex Diseases by Integrating Multiple Types of Genomic Data [C] . Hongbao Cao, Shufeng Lei, Hong-Wen Deng, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2012

机译：通过整合多种基因组数据来鉴定复杂疾病的基因
5. Efficient use of genetic data for mapping complex traits: Improved data management, significance testing for marker allele sharing statistics, and estimation of kinship coefficients. [D] . Day-Williams, Aaron Garth. 2009

机译：有效利用遗传数据绘制复杂性状：改进数据管理，标记等位基因共享统计数据的显着性测试以及亲属系数估计。
6. Identification of Genes for Complex Diseases Using Integrated Analysis of Multiple Types of Genomic Data [O] . Hongbao Cao, Shufeng Lei, Hong-Wen Deng, -1

机译：基因的复杂疾病使用基因组数据的多种类型的综合分析鉴定
7. Toward the identification of causal genes in complex diseases: a gene-centric joint test of significance combining genomic and transcriptomic data [O] . 2009

机译：鉴定复杂疾病中的致病基因：以基因为中心的联合检验，结合基因组和转录组数据进行显着性检验

Toward the identification of causal genes in complex diseases: a gene-centric joint test of significance combining genomic and transcriptomic data

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