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Protocol for a randomized controlled trial of early prophylactic feeding via gastrostomy versus standard care in high risk patients with head and neck cancer

机译：高风险头颈部癌患者通过胃造口术和标准治疗进行早期预防性喂养的随机对照试验方案

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BackgroundPatients with head and neck cancer are at high risk of malnutrition and dysphagia. Enteral tube feeding via a gastrostomy or nasogastric tube is often required in response to dysphagia, odynophagia or side effects of treatment that lead to dehydration and/or weight-loss. A recent systematic review concluded that the optimal method of tube feeding remains unclear; however prophylactic gastrostomy, placed in anticipation of its use during and after treatment, is common practice, following a number of demonstrated benefits. However the majority of these studies have been undertaken in patients receiving radiotherapy alone. More recent studies in patient populations receiving concurrent chemoradiotherapy are showing that despite prophylactic gastrostomy placement significant weight loss still occurs, placing the patient at risk of the consequences of malnutrition. Therefore we set out to investigate innovative prophylactic nutrition support via the gastrostomy to optimise the nutritional outcomes of patients with head and neck cancer.
机译：背景患有头颈癌的患者营养不良和吞咽困难的风险很高。对于吞咽困难，吞咽困难或导致脱水和/或体重减轻的治疗副作用，通常需要通过胃造口术或鼻胃管进行肠管喂养。最近的一项系统评价得出结论，管饲的最佳方法仍不清楚。然而，预防性胃造口术在治疗期间和治疗后预期会被使用，这是继许多已证明的益处之后的普遍做法。然而，这些研究大多数是在仅接受放射治疗的患者中进行的。在接受同步放化疗的患者人群中，更近期的研究表明，尽管进行了预防性胃造口术，但体重仍然显着下降，使患者处于营养不良后果的风险中。因此，我们着手通过胃造口术研究创新的预防性营养支持，以优化头颈癌患者的营养结果。

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