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Long descending cervical propriospinal neurons differ from thoracic propriospinal neurons in response to low thoracic spinal injury

机译:长期下降的颈椎脊髓神经元与胸椎脊髓神经元的区别在于对低胸椎损伤的反应

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摘要

BackgroundPropriospinal neurons, with axonal projections intrinsic to the spinal cord, have shown a greater regenerative response than supraspinal neurons after axotomy due to spinal cord injury (SCI). Our previous work focused on the response of axotomized short thoracic propriospinal (TPS) neurons following a low thoracic SCI (T9 spinal transection or moderate spinal contusion injury) in the rat. The present investigation analyzes the intrinsic response of cervical propriospinal neurons having long descending axons which project into the lumbosacral enlargement, long descending propriospinal tract (LDPT) axons. These neurons also were axotomized by T9 spinal injury in the same animals used in our previous study.
机译:背景由于脊髓损伤(SCI),轴突后脊髓固有的轴突前神经元比脊髓上神经元显示出更大的再生反应。我们以前的工作集中于在大鼠中低胸腔脊髓损伤(T9脊髓横断或中度脊髓挫伤性损伤)后无轴索化的短胸脊椎脊髓(TPS)神经元的反应。本研究分析了具有长下降轴突的颈椎脊髓神经元的内在反应,该神经突突伸入腰ment部膨大,长下降脊索道(LDPT)轴突。在我们先前研究中使用的相同动物中,这些神经元也因T9脊髓损伤而被轴突切除。

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