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Incidence of total hip and total knee replacements from the prospective epidemiologic risk factor study: considerations for event driven clinical trial design

机译：前瞻性流行病学危险因素研究中全髋关节和全膝关节置换术的发生率：事件驱动型临床试验设计的考虑因素

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BackgroundOsteoarthritis (OA) leads to joint failure and total joint replacement (TJR, either hip (H) or knee (K)). Worsening of pain and joint space narrowing are believed to be surrogates for joint failure; however, we hypothesize that TJR, as a reflection of joint failure, can be used as an endpoint in event-driven clinical trials within a reasonable duration. We explored the incidence of TJR in the Prospective Epidemiologic Risk Factor (PERF I) study.

机译：背景骨关节炎（OA）会导致关节衰竭和全关节置换（TJR，髋部（H）或膝部（K））。疼痛加剧和关节间隙狭窄被认为是关节衰竭的代名词。然而，我们假设TJR作为关节衰竭的反映，可以在合理的时间内用作事件驱动型临床试验的终点。我们在前瞻性流行病学危险因素（PERF I）研究中探讨了TJR的发生率。

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期刊名称 BMC Musculoskeletal Disorders
作者
Cecilie L. Bager; Morten Karsdal; Asger Bihlet; Christian Thudium; Inger Byrjalsen; Anne C. Bay-Jensen;
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作者单位

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年(卷),期 2019(20),-1
年度 2019
页码 303
总页数 6
原文格式 PDF
正文语种
中图分类矫形学;免疫性疾病;
关键词
Total joint replacements Osteoarthritis Clinical trial design Postmenopausal women Register;

机译：关节置换术;骨关节炎;临床试验设计;绝经后妇女;注册;

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专利

1. Incidence of total hip and total knee replacements from the prospective epidemiologic risk factor study: considerations for event driven clinical trial design [J] . Cecilie L. Bager, Morten Karsdal, Asger Bihlet, BMC Musculoskeletal Disorders . 2019,第1期

机译：从前瞻性流行病学风险因素研究中的总髋髋和全膝关节的发生率：事件驱动临床试验设计的考虑因素
2. Incidence, risk factors and the healthcare cost of falls postdischarge after elective total hip and total knee replacement surgery: protocol for a prospective observational cohort study [J] . Gail Ross-Adjie, Gerard Hardisty, Leanne Monterosso, BMJ Open . 2016,第7期

机译：全髋关节置换术和全膝关节置换术后出院后跌倒的发生率，风险因素和医疗保健费用：一项前瞻性观察性队列研究的方案
3. TOTAL JOINT REPLACEMENT (TJR) AS CLINICAL ENDPOINT IN OA; PREVALENCE AND INCIDENCE RATES OF TJRS FROM THE PROSPECTIVE EPIDEMIOLOGIC RISK FACTOR (PERF I) STUDY [J] . Bay-Jensen A. -C., Bager C., Bihlet A., Osteoarthritis and cartilage . 2018,第Suppla1期

机译：总关节替代（TJR）作为OA的临床终点; 从前瞻性流行病风险因素（PERF I）研究中的TJRS患病率和发病率
4. First clinical experiences with a new advanced tracking device in navigated total knee and total hip replacement [C] . Thomas Mattes, Oliver Ostertag, Ralf Decking, International Society for Computer Assisted Orthopaedic Surgery. Meeting . 2007

机译：第一次临床经验，采用新的先进跟踪装置在导航的全膝部和总髋关节置换中
5. How Well Does Kinematically Aligned Total Knee Arthroplasty Prevent Clinically Important Changes in Passive Knee Function? An In Vitro Biomechanical Study of Tibiofemoral Laxities and Contact. [D] . Roth, Joshua Daniel. 2016

机译：运动学对准的全膝关节置换术如何很好地预防被动膝功能的临床重要变化？胫骨股骨松弛和接触的体外生物力学研究。
6. Incidence risk factors and the healthcare cost of falls postdischarge after elective total hip and total knee replacement surgery: protocol for a prospective observational cohort study [O] . Anne-Marie Hill, Gail Ross-Adjie, Steven M McPhail, 2016

机译：全髋关节置换术和全膝置换术后出院后跌倒的发生率风险因素和医疗保健费用：一项前瞻性观察性队列研究的方案
7. Incidence, risk factors and the healthcare cost of falls postdischarge after elective total hip and total knee replacement surgery: Protocol for a prospective observational cohort study [O] . Hill Anne-Marie, Ross-Adjie Gail, McPhail Steven M., 2016

机译：全髋关节置换术和全膝关节置换术后出院后跌倒的发生率，风险因素和医疗保健费用：一项前瞻性观察性队列研究的方案

Incidence of total hip and total knee replacements from the prospective epidemiologic risk factor study: considerations for event driven clinical trial design

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