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Lysis-deficient phages as novel therapeutic agents for controlling bacterial infection

机译：裂解不足的噬菌体作为控制细菌感染的新型治疗剂

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BackgroundInterest in phage therapy has grown over the past decade due to the rapid emergence of antibiotic resistance in bacterial pathogens. However, the use of bacteriophages for therapeutic purposes has raised concerns over the potential for immune response, rapid toxin release by the lytic action of phages, and difficulty in dose determination in clinical situations. A phage that kills the target cell but is incapable of host cell lysis would alleviate these concerns without compromising efficacy.

机译：背景技术由于细菌病原体中抗生素耐药性的迅速出现，过去十年来噬菌体治疗的兴趣不断增长。然而，出于治疗目的使用噬菌体引起了对免疫应答的潜力，通过噬菌体的溶解作用快速释放毒素以及在临床情况下确定剂量的困难的关注。杀死靶细胞但不能进行宿主细胞裂解的噬菌体将在不影响功效的情况下减轻这些担忧。

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期刊名称 BMC Microbiology
作者
Vivek Daniel Paul; Sudarson Sundarrajan; Sanjeev Saravanan Rajagopalan; Sukumar Hariharan; Nanjundappa Kempashanaiah; Sriram Padmanabhan; Bharathi Sriram; Janakiraman Ramachandran;
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年(卷),期 2011(11),-1
年度 2011
页码 195
总页数 9
原文格式 PDF
正文语种
中图分类微生物学;
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专利

1. Lysis-deficient phages as novel therapeutic agents for controlling bacterial infection [J] . Vivek D Paul, Sudarson Sundarrajan, Sanjeev S Rajagopalan, BMC Microbiology . 2011,第1期

机译：裂解不足的噬菌体作为控制细菌感染的新型治疗剂
2. Use of genetically engineered phage to deliver antimicrobial agents to bacteria: an alternative therapy for treatment of bacterial infections. [J] . Westwater C, Kasman LM, Schofield DA, Antimicrobial agents and chemotherapy. . 2003,第4期

机译：使用基因工程噬菌体向细菌输送抗微生物剂：治疗细菌感染的另一种疗法。
3. Phage therapy: safe viruses help to control bacterial infections [J] . Bergen M. van, Wagenaar J. Tijdschrift voor Diergeneeskunde . 2008,第14a15期

机译：噬菌体疗法：安全的病毒有助于控制细菌感染
4. Controlled release of novel anti-biofilm agents from a poly (2-hydroxyethyl methacrylate) Scaffold for the treatment of medical device associated bacterial biofilm infections [C] . Hongyan Ma, Lei zhang, Min zhang, Society for Biomaterials annual meeting and exposition . 2013

机译：从聚甲基丙烯酸2-羟乙酯支架中控制释放新型抗生物膜剂，用于治疗与医疗器械相关的细菌生物膜感染
5. Bacterial detection using phage display for the differentiation of pre- and post-infection bacteriophages: A model M13 system. [D] . Shroyer, Melinda L. 2006

机译：使用噬菌体展示进行细菌检测以区分感染前和感染后的噬菌体：M13模型系统。
6. Use of Genetically Engineered Phage To Deliver Antimicrobial Agents to Bacteria: an Alternative Therapy for Treatment of Bacterial Infections [O] . Caroline Westwater, Laura M. Kasman, David A. Schofield, 2003

机译：基因工程噬菌体向细菌输送抗菌剂的使用：细菌感染治疗的替代疗法。
7. Lysis-deficient phages as novel therapeutic agents for controlling bacterial infection [O] . Vivek Paul, Sudarson Sundarrajan, Sanjeev Rajagopalan, 2011

机译：裂解不足的噬菌体作为控制细菌感染的新型治疗剂
8. GENETIC ANALYSIS OF MICROORGANISM BY MIXED INFECTION OF ACTIVE PHAGE PARTICLES AND PHAGE OR BACTERIAL DNA [R] . Isamu Kondo 1965

机译：活性芽颗粒与细菌或细菌DNa混合感染的微生物遗传分析

Lysis-deficient phages as novel therapeutic agents for controlling bacterial infection

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