Loss of heterozygosity: what is it good for?

机译：失去杂合性：这有什么用？

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摘要

BackgroundLoss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type alleles in many inherited cancer syndromes. The wider involvement of LOH in cancer is assumed to relate to unmasking a somatically mutated tumour suppressor gene through loss of the wild type allele.

机译：背景杂合性缺失（LOH）是癌症发展中的常见遗传事件，已知与许多遗传性癌症综合征中的野生型等位基因发生体细胞丢失有关。 LOH在癌症中的广泛参与被认为与通过丧失野生型等位基因来揭示体细胞突变的肿瘤抑制基因有关。

著录项

期刊名称 BMC Medical Genomics
作者
Georgina L. Ryland; Maria A. Doyle; David Goode; Samantha E. Boyle; David Y.H. Choong; Simone M. Rowley; Jason Li; David DL Bowtell; Richard W. Tothill; Ian G. Campbell; Kylie L. Gorringe;
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作者单位

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年(卷),期 2015(8),-1
年度 2015
页码 45
总页数 12
原文格式 PDF
正文语种
中图分类遗传学;
关键词
Tumour suppressor gene SNP Ovarian cancer Mutation Haploinsufficiency;

机译：肿瘤抑制基因;SNP;卵巢癌;突变;单倍体不足;

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专利

1. Mass Spectrometry-Based Loss of Heterozygosity Analysis of Single-Nucleotide Polymorphism Loci in Paraffin Embedded Tumors Using the MassEXTEND Assay Single-Nucleotide Polymorphism Loss of Heterozygosity Analysis of the Protein Tyrosine Phosphatase Receptor Type J in Familial Colorectal Cancer [J] . Marjo van Puijenbroek* Jan Willem F. Dierssen* Patrick Stanssens Ronald van Eijk* Anne Marie Cleton-Jansen* Tom van Wezel* and Hans Morreau* Journal of Molecular Diagnostics . 2005,第5期

机译：使用MassEXTEND分析基于质谱的石蜡包埋的肿瘤中单核苷酸多态性位点杂合度损失分析酪氨酸磷酸化酶受体J型蛋白在家族性结直肠癌中单核苷酸多态性杂合度分析的损失
2. Mass spectrometry-based loss of heterozygosity analysis of single-nucleotide polymorphism loci in paraffin embedded tumors using the MassEXTEND assay: single-nucleotide polymorphism loss of heterozygosity analysis of the protein tyrosine phosphatase [J] . van-Puijenbroek M, Dierssen JW, Stanssens P, The Journal of molecular diagnostics: JMD . 2005,第5期

机译：基于质谱的石蜡包埋的肿瘤中单核苷酸多态性位点杂合度损失的质谱分析：蛋白酪氨酸磷酸酶杂合性的单核苷酸多态性损失分析
3. Heterozygosity of p16 expression in an oral squamous cell carcinoma with associated loss of heterozygosity and copy number alterations [J] . Ambele Melvin A., Pepper Michael S., Heerden Marlene B., Head and neck: Journal for the sciences and specialities of the head and neck . 2019,第5期

机译：口腔鳞状细胞癌中P16表达的杂合性，杂合性损失和拷贝数改变
4. A Mixed Integer Programming Model for the Parsimonious Loss of Heterozygosity Problem [C] . Daniele Catanzaro, Martine Labbe, Bjarni V. Halldorsson Bioinformatics research and applications. . 2012

机译：杂合性问题的简约损失的混合整数规划模型
5. The Effect of Skewed Elevation in dNTP Pools on Loss of Heterozygosity in Saccharomyces cerevisiae [D] . Badar, Jumana. 2018

机译：dNTP库中偏斜升高对酿酒酵母杂合性丧失的影响
6. Loss of Heterozygosity or Allele Imbalance in Histologically Normal Breast Epithelium Is Distinct from Loss of Heterozygosity or Allele Imbalance in Co-Existing Carcinomas [O] . Pamela S. Larson, Antonio de las Morenas, Sheila R. Bennett, 2002

机译：组织学上正常的乳腺上皮的杂合性或等位基因失衡与并存癌的杂合性或等位基因失衡是不同的
7. Immune deficiency augments the prevalence of p53 loss of heterozygosity in spontaneous tumors but not bi-directional loss of heterozygosity in bone marrow progenitors [O] . Yoav Shetzer, Yael Napchan, Tom Kaufman, 2017

机译：免疫缺陷增加了自发肿瘤中P53杂合性的p53丧失的患病率，但不是骨髓祖细胞杂合子的双向丧失

Loss of heterozygosity: what is it good for?

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