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Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection

机译：对甲型流感病毒感染易感性较弱的p53缺陷小鼠免疫相关基因表达的转录分析

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摘要

Backgroundp53 is a tumor suppressor that contributes to the host immune response against viral infections in addition to its well-established protective role against cancer development. In response to influenza A virus (IAV) infection, p53 is activated and plays an essential role in inhibiting IAV replication. As a transcription factor, p53 regulates the expression of a range of downstream responsive genes either directly or indirectly in response to viral infection. We compared the expression profiles of immune-related genes between IAV-infected wild-type p53 (p53WT) and p53-deficient (p53KO) mice to gain an insight into the basis of p53-mediated antiviral response.

机译：Backgroundp53是一种肿瘤抑制因子，除了其公认的针对癌症发展的保护作用外，还有助于宿主抵抗病毒感染的免疫反应。响应甲型流感病毒（IAV）感染，p53被激活并在抑制IAV复制中起重要作用。作为转录因子，p53直接或间接调节病毒感染后的下游反应基因的表达。我们比较了IAV感染的野生型p53（p53WT）和p53缺陷（p53KO）小鼠之间免疫相关基因的表达谱，以深入了解p53介导的抗病毒反应的基础。

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期刊名称 BMC Medical Genomics
作者
Wenjun Yan; Jianchao Wei; Xufang Deng; Zixue Shi; Zixiang Zhu; Donghua Shao; Beibei Li; Shaohui Wang; Guangzhi Tong; Zhiyong Ma;
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年(卷),期 2015(8),-1
年度 2015
页码 52
总页数 10
原文格式 PDF
正文语种
中图分类遗传学;
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专利

1. Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection [J] . Wenjun Yan, Jianchao Wei, Xufang Deng, BMC Medical Genomics . 2015,第1期

机译：转录分析分析p53缺陷小鼠对甲型流感病毒感染的易感性与免疫相关基因的表达
2. RNAseq expression analysis of resistant and susceptible mice after influenza A virus infection identifies novel genes associated with virus replication and important for host resistance to infection [J] . Esther Wilk, Ashutosh K. Pandey, Sarah Rebecca Leist, BMC Genomics . 2015,第1期

机译：甲型流感病毒感染后耐药和易感小鼠的RNAseq表达分析可鉴定与病毒复制相关的新基因，对宿主抵抗感染具有重要意义
3. Analysis of immune-related ESTs and differential expression analysis of few important genes in lines of rohu (Labeo rohita) selected for resistance and susceptibility to Aeromonas hydrophila infection [J] . Das Sweta, Chhottaray Chiranjibi, Das Mahapatra Kanta, Molecular biology reports . 2014,第11期

机译：针对嗜水气单胞菌感染的耐药性和敏感性选择的Rohu（Labeo rohita）品系中与免疫相关的ESTs分析和一些重要基因的差异表达分析
4. VACCINATION WITH RECOMBINANT NEURAMINIDASE PROTECTS AGAINST INFLUENZA VIRUS INFECTION IN MICE [C] . Teddy John Wohlbold, Veronika Chromikova, Philip Meade, Vaccine technology VI . 2016

机译：用重组神经氨酸酶疫苗免疫小鼠流感病毒感染
5. Conditional Disruption of Hem-1 Results in Impaired Development of Alveolar Macrophages, Pulmonary Alveolar Proteinosis, and Increased Susceptibility to Influenza Virus Infection [D] . Suwankitwat, Nutthakarn . 2019

机译：条件破坏HEM-1导致肺泡巨噬细胞，肺肺泡蛋白病的发育受损，对流感病毒感染的易感性增加
6. RNAseq expression analysis of resistant and susceptible mice after influenza A virus infection identifies novel genes associated with virus replication and important for host resistance to infection [O] . Esther Wilk, Ashutosh K. Pandey, Sarah Rebecca Leist, 2015

机译：甲型流感病毒感染后耐药和易感小鼠的RNAseq表达分析可鉴定与病毒复制相关的新基因并且对宿主抵抗感染具有重要意义
7. Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection [O] . Wenjun Yan, Jianchao Wei, Xufang Deng, 2015

机译：对甲型流感病毒感染易感性较弱的p53缺陷小鼠免疫相关基因表达的转录分析
8. Effect of Prior Influenza Virus Infection on Susceptibility of AKR/J Mice and Squirrel Monkeys to Respiratory Challenge with Legionella pneumophila [R] . Berendt, R. F. 1980

机译：先前流感病毒感染对aKR / J小鼠和松鼠猴对嗜肺军团菌呼吸道攻击的敏感性的影响

Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection

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