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In vitro analysis of the proliferative capacity and cytotoxic effects of ex vivo induced natural killer cells cytokine-induced killer cells and gamma-delta T cells

机译：体外分析离体诱导的自然杀伤细胞细胞因子诱导的杀伤细胞和γ-δT细胞的增殖能力和细胞毒性作用

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摘要

BackgroundRecent studies have focused on the significant cytotoxicity of natural killer (NK) cells, cytokine-induced killer (CIK) cells, and gamma-delta (γδ) T cells in tumor cells. Nevertheless, the therapeutic features of these cell types have not been compared in the literature. The aim of this study was to evaluate the feasibility of activation and expansion of NK, CIK, and γδ T cells from cancer patients in vitro, and to clarify the differences in their antitumor capacities.

机译：背景技术最近的研究集中在肿瘤细胞中自然杀伤（NK）细胞，细胞因子诱导的杀伤（CIK）细胞和γ-δ（γδ）T细胞的显着细胞毒性。然而，这些细胞类型的治疗特征尚未在文献中进行比较。这项研究的目的是评估体外癌症患者NK，CIK和γδT细胞活化和扩增的可行性，并阐明其抗肿瘤能力的差异。

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期刊名称 BMC Immunology
作者
Chao Niu; Haofan Jin; Min Li; Jianting Xu; Dongsheng Xu; Jifan Hu; Hua He; Wei Li; Jiuwei Cui;
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作者单位

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年(卷),期 2015(16),-1
年度 2015
页码 61
总页数 10
原文格式 PDF
正文语种
中图分类免疫学;
关键词
Natural killer cells Cytokine-induced killer cells Gamma-delta T cells Cytotoxicity;

机译：天然杀伤细胞;细胞因子诱导的杀伤细胞;γ-δT细胞;细胞毒性;

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专利

1. In vitro analysis of the proliferative capacity and cytotoxic effects of ex vivo induced natural killer cells, cytokine-induced killer cells, and gamma-delta T cells [J] . Chao Niu, Haofan Jin, Min Li, BMC Immunology . 2015,第1期

机译：体外分析离体诱导的天然杀伤细胞，细胞因子诱导的杀伤细胞和γ-δT细胞的增殖能力和细胞毒性作用
2. Th1 polarization and apoptosis-inducing activity of CD4+ T -cells in cytokine-induced killers might favor the antitumor cytotoxicity of cytokine-induced killers in vivo. [J] . Yu J, Ren X, Cao S, Cancer biotherapy and radiopharmaceuticals . 2006,第3期

机译：细胞因子诱导的杀伤细胞中CD4 + T细胞的Th1极化和诱导细胞凋亡的活性可能有利于细胞因子诱导的杀伤剂在体内的抗肿瘤细胞毒性。
3. Cytokine-induced killer cells/dendritic cells and cytokine-induced killer cells immunotherapy for the treatment of esophageal cancer in China: a meta-analysis [J] . Yan Liu, Ying Mu, Anqi Zhang, OncoTargets and therapy . 2017,第2期

机译：细胞因子诱导的杀伤细胞/树突状细胞和细胞因子诱导的杀伤细胞免疫疗法在中国食管癌治疗中的Meta分析
4. Anti-breast tumor activities of CpG ODN-activated dendritic cells co-cultured with cytokine-induced killer cells in vitro and in vivo [C] . Gabriele Ghisellini Asian Pacific Confederation of Chemical Engineering congress . 2008

机译：CpG ODN激活的树突状细胞与细胞因子诱导的杀伤细胞在体外和体内共培养的抗乳腺癌肿瘤活性
5. gammadelta T cells derived from peripheral blood and cerebrospinal fluid of multiple sclerosis patients: Cytotoxic mechanisms, inhibitory natural killer cell receptors, and protein analysis. [D] . Green, Melanie Leslie Dawn. 2005

机译：多发性硬化症患者外周血和脑脊液中产生的γT细胞：细胞毒性机制，抑制性自然杀伤细胞受体和蛋白质分析。
6. The cytotoxic action of the CD56+ fraction of cytokine-induced killer cells against a K562 cell line is mainly restricted to the natural killer cell subset [O] . Katia Chieregato, Cristina Zanon, Silvia Castegnaro, 2017

机译：细胞因子诱导的杀伤细胞CD56 +组分对K562细胞系的细胞毒作用主要限于自然杀伤细胞亚群
7. In vitro analysis of the proliferative capacity and cytotoxic effects of ex vivo induced natural killer cells, cytokine-induced killer cells, and gamma-delta T cells [O] . 2015

机译：体外分析离体诱导的天然杀伤细胞，细胞因子诱导的杀伤细胞和γ-δT细胞的增殖能力和细胞毒性作用
8. Manganese Chloride Enhances Murine Cell-Mediated Cytotoxicity: Effects on Natural Killer Cells [R] . Smialowicz, R. J. , Rogers, R. R. , Riddle, M. M. , 1984

机译：氯化锰增强小鼠细胞介导的细胞毒性：对自然杀伤细胞的影响

In vitro analysis of the proliferative capacity and cytotoxic effects of ex vivo induced natural killer cells cytokine-induced killer cells and gamma-delta T cells

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