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Benzo ... formula ... pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice

机译：苯并pyr诱导的靶标和非靶标器官中的DNA加合物和基因表达谱在小鼠中致癌

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BackgroundGene expression changes induced by carcinogens may identify differences in molecular function between target and non-target organs. Target organs for benzo[a]pyrene (BaP) carcinogenicity in mice (lung, spleen and forestomach) and three non-target organs (liver, colon and glandular stomach) were investigated for DNA adducts by ³²P-postlabelling, for gene expression changes by cDNA microarray and for miRNA expression changes by miRNA microarray after exposure of animals to BaP.

机译：背景由致癌物引起的基因表达变化可以识别靶器官和非靶器官之间分子功能的差异。通过^{32 P研究了小鼠（肺，脾脏和前胃癌）和三个非靶器官（肝，结肠和腺胃）中苯并[a] py（BaP）致癌性的靶器官中的DNA加合物。 -后标记，用于在将动物暴露于BaP后通过cDNA微阵列改变基因表达并通过miRNA微阵列改变miRNA表达。}

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期刊名称 BMC Genomics
作者
Jie Zuo; Daniel S Brewer; Volker M Arlt; Colin S Cooper; David H Phillips;
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作者单位

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年(卷),期 2014(15),1
年度 2014
页码 880
总页数 21
原文格式 PDF
正文语种
中图分类遗传学;应用微生物学;
关键词
Carcinogenicity Organotropism Benzoapyrene DNA adducts Gene expression Microarray miRNA;

机译：致癌性;趋向性;苯并a re;DNA加合物;基因表达;微阵列;miRNA;

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专利

1. Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice [J] . Jie Zuo, Daniel S Brewer, Volker M Arlt, BMC Genomics . 2014,第1期

机译：苯并芘诱导的DNA加合物和基因表达谱系在靶和非靶器官中的小鼠中的致癌作用
2. Differences in gene expression and benzo(a)pyrene-induced DNA adduct formation in the liver of three strains of female mice with identical AhRb2 genotype treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and/or benzo(a)pyrene. [J] . Wu Q, Suzuki JS, Zaha H, Journal of applied toxicology . 2008,第6期

机译：2,3,7,8-四氯二苯并-对-二恶英和/或苯并（a）处理的三只具有相同AhRb2基因型的雌性小鼠的肝脏中基因表达和苯并（a）induced诱导的DNA加合物形成的差异.。
3. STUDIES ON THE SUSCEPTIBILITY OF VARIOUS ORGANS OF ZEBRAFISH (Brachydanio rerio ) TO BENZO(A)PYRENE-INDUCED DNA ADDUCT FORMATION [J] . Todd Hsu, Fuh-Yeu Deng Chemosphere . 1996,第10期

机译：斑马鱼（Brachydanio rerio）的各种有机物对苯并（A）P诱导的DNA形成的敏感性研究
4. The effects benzo(a)pyrenediolexpoxide exposure on DNA adduct formation, altered gene expression, and toxicity in human lymphoblastoid TK6 cells. [C] . Joshua J Klaene, Jennifer Barrett, Caroline Ceailles Flakaros, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：苯并（a）Pyrenyiolexpatiene暴露在DNA加合物形成，改变基因表达和人淋巴细胞Tk6细胞中的效果暴露。
5. Benzo(a)pyrene and benzo(a)pyrene-induced protein adducts in hair as biomarkers of toxic benzo(a)pyrene exposures. [D] . Campbell, Sarah Colleen. 2011

机译：苯并（a）and和苯并（a）-诱导的头发蛋白质加合物是有毒苯并（a）exposure暴露的生物标志物。
6. Inhibitory effects of polysaccharides isolated from Phellinus gilvus on benzo(a)pyrene-induced forestomach carcinogenesis in mice [O] . Jae-Sung Bae, Kwang-Ho Jang, Hyunee Yim, 2005

机译：桑黄多糖对苯并（a）py诱导的前胃癌致癌作用的抑制作用
7. Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice [O] . 2014

机译：苯并pyr诱导的目标和非目标器官中的DNA加合物和基因表达谱在小鼠中致癌
8. Ki-ras Oncogene Mutations in Tumors and DNA Adducts Formed byBenz(i)aceanthrylene and Benzo(a)pyrene in the Lungs of Strain A/J Mice [R] . Mass, M. J., Jeffers, A. J., Ross, J. A., 1993

机译：肿瘤中的Ki-ras癌基因突变和由菌株a / J小鼠肺中的苯并（a）乙炔和苯并（a）芘形成的DNa加合物

Benzo ... formula ... pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice

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