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Historical perspective on heart function: the Frank–Starling Law

机译：心脏功能的历史观点：弗兰克·史达琳法则

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More than a century of research on the Frank–Starling Law has significantly advanced our knowledge about the working heart. The Frank–Starling Law mandates that the heart is able to match cardiac ejection to the dynamic changes occurring in ventricular filling and thereby regulates ventricular contraction and ejection. Significant efforts have been attempted to identify a common fundamental basis for the Frank–Starling heart and, although a unifying idea has still to come forth, there is mounting evidence of a direct relationship between length changes in individual constituents (cardiomyocytes) and their sensitivity to Ca2+ ions. As the Frank–Starling Law is a vital event for the healthy heart, it is of utmost importance to understand its mechanical basis in order to optimize and organize therapeutic strategies to rescue the failing human heart. The present review is a historic perspective on cardiac muscle function. We “revive” a century of scientific research on the heart’s fundamental protein constituents (contractile proteins), to their assemblies in the muscle (the sarcomeres), culminating in a thorough overview of the several synergistically events that compose the Frank–Starling mechanism. It is the authors’ personal beliefs that much can be gained by understanding the Frank–Starling relationship at the cellular and whole organ level, so that we can finally, in this century, tackle the pathophysiologic mechanisms underlying heart failure.
机译：对弗兰克·史达琳法则的研究已有一百多年的历史，大大提高了我们对工作心脏的认识。弗兰克-史太林法规定，心脏必须能够使心脏射血与心室充盈中发生的动态变化相匹配，从而调节心室的收缩和射血。已经尝试了巨大的努力来确定弗兰克-史达琳心脏的共同基本基础，尽管仍然有一个统一的想法，但越来越多的证据表明，单个成分（心肌细胞）的长度变化与其对血管的敏感性之间存在直接关系。 Ca 2 + 离子。由于弗兰克·史达琳法则对心脏健康至关重要，因此了解其机械基础以优化和组织治疗策略以挽救人的心脏衰竭至关重要。本综述是关于心肌功能的历史性观点。我们“复兴”了一个世纪的科学研究，对心脏的基本蛋白质成分（收缩性蛋白质）及其在肌肉中的组合（肉瘤）进行了总结，最后对构成Frank-Starling机制的若干协同事件进行了全面概述。作者的个人信念是，在细胞和整个器官水平上了解弗兰克-史达琳的关系可以带来很多好处，因此我们最终可以在本世纪解决心力衰竭的病理生理机制。

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