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Study on the interaction between active components from traditional Chinese medicine and plasma proteins

机译：中药有效成分与血浆蛋白相互作用的研究

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摘要

Traditional Chinese medicine (TCM), as a unique form of natural medicine, has been used in Chinese traditional therapeutic systems over two thousand years. Active components in Chinese herbal medicine are the material basis for the prevention and treatment of diseases. Research on drug-protein binding is one of the important contents in the study of early stage clinical pharmacokinetics of drugs. Plasma protein binding study has far-reaching influence on the pharmacokinetics and pharmacodynamics of drugs and helps to understand the basic rule of drug effects. It is important to study the binding characteristics of the active components in Chinese herbal medicine with plasma proteins for the medical science and modernization of TCM. This review summarizes the common analytical methods which are used to study the active herbal components-protein binding and gives the examples to illustrate their application. Rules and influence factors of the binding between different types of active herbal components and plasma proteins are summarized in the end. Finally, a suggestion on choosing the suitable technique for different types of active herbal components is provided, and the prospect of the drug-protein binding used in the area of TCM research is also discussed.
机译：中医（TCM）作为一种独特的天然药物，已经在中医传统治疗系统中使用了两千多年。中草药中的有效成分是预防和治疗疾病的物质基础。药物-蛋白质结合的研究是药物早期临床药代动力学研究的重要内容之一。血浆蛋白结合研究对药物的药代动力学和药效学具有深远的影响，有助于理解药物作用的基本规律。研究中草药活性成分与血浆蛋白的结合特性对于医学和中医药现代化具有重要意义。这篇综述总结了用于研究活性草药成分-蛋白质结合的常用分析方法，并举例说明了它们的应用。最后总结了不同类型的活性草药成分与血浆蛋白结合的规律和影响因素。最后，提出了针对不同类型的活性草药成分选择合适技术的建议，并讨论了中药研究领域药物-蛋白质结合的前景。

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