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首页> 外文期刊>Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis >Analysis of bioactive components and pharmacokinetic study of herb-herb interactions in the traditional Chinese patent medicine Tongmai Yangxin Pill
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Analysis of bioactive components and pharmacokinetic study of herb-herb interactions in the traditional Chinese patent medicine Tongmai Yangxin Pill

机译：中国中药阳新丸中药中草药互动的生物活性成分及药代动力学研究分析

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摘要

Tongmai Yangxin (TMYX) Pill is a traditional Chinese patent medicine, composed of eleven Chinese medicinal herbs. It has been used to treat coronary heart disease for several decades. In this study, six male Sprague-Dawley rats were dosed orally with TMYX methanol extract, and a serum pharmacochemistry technique was used to screen absorbed bioactive compounds by UPLC/Q-TOF-MS. By comparing MS spectra to the published literature data, 40 bioactive components were identified. The results indicated that almost 45% of the absorbed compounds were from Radix Glycyrrhizae (GC). Subsequently, a reliable HPLC method was used to determine the concentrations of liquiritin, liquiritigenin, isoliquiritigenin, glycyrrhizic acid, and glycyrrhetinic acid in rat plasma following oral administration of GC or the combination of GC and Ramulus Cinnamomi (GZ). The results showed that GZ enhanced the absorption of four bioactive components: liquiritigenin, isoliquiritigenin, glycyrrhizic acid, and glycyrrhetinic acid. The data demonstrate that herb combination in TMYX Pill exhibit a synergistic action. (C) 2015 Elsevier B.V. All rights reserved.
机译：桐树阳金（TMYX）丸是一种传统的中国专利药物，由11例中药草药组成。它已被用来治疗冠心病几十年。在这项研究中，用TMYX甲醇提取物口服六只雄性Sprague-Dawley大鼠，用UPLC / Q-TOF-MS进行血清药物化学技术筛选吸收的生物活性化合物。通过将MS光谱与发表的文献数据进行比较，确定了40种生物活性组分。结果表明，近45％的吸收化合物来自甘草糖（GC）。随后，使用可靠的HPLC方法来确定在口服GC或GC和Raculus Cinnamomi（GZ）的组合之后大鼠血浆中大鼠血浆中的液体素，液中素，孤立替代菌蛋白，甘草酸和甘草酸的浓度。结果表明，GZ增强了四种生物活性成分的吸收：液中素，Isliquiritigenin，甘草酸和甘草酸和甘草酸。数据表明，TMYX丸中的草药组合表现出协同作用。 （c）2015 Elsevier B.v.保留所有权利。

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