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首页> 美国卫生研究院文献>Proceedings of the Royal Society B: Biological Sciences >Neural sensitivity to sex steroids predicts individual differences in aggression: implications for behavioural evolution
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Neural sensitivity to sex steroids predicts individual differences in aggression: implications for behavioural evolution

机译：对性类固醇的神经敏感性预测攻击的个体差异：对行为进化的影响

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Testosterone (T) regulates many traits related to fitness, including aggression. However, individual variation in aggressiveness does not always relate to circulating T, suggesting that behavioural variation may be more closely related to neural sensitivity to steroids, though this issue remains unresolved. To assess the relative importance of circulating T and neural steroid sensitivity in predicting behaviour, we measured aggressiveness during staged intrusions in free-living male and female dark-eyed juncos (Junco hyemalis). We compared aggressiveness to plasma T levels and to the abundance of androgen receptor (AR), aromatase (AROM) and oestrogen receptor alpha (ORα) mRNA in behaviourally relevant brain areas (avian medial amygdala, hypothalamus and song control regions). We also asked whether patterns of covariation among behaviour and endocrine parameters differed in males and females, anticipating that circulating T may be a better predictor of behaviour in males than in females. We found that circulating T related to aggressiveness only in males, but that gene expression for ORα, AR and AROM covaried with individual differences in aggressiveness in both sexes. These findings are among the first to show that individual variation in neural gene expression for three major sex steroid-processing molecules predicts individual variation in aggressiveness in both sexes in nature. The results have broad implications for our understanding of the mechanisms by which aggressive behaviour may evolve.
机译：睾丸激素（T）调节与健身相关的许多特征，包括攻击性。但是，个体攻击性变化并不总是与循环T相关，这表明行为变化可能与对类固醇的神经敏感性更紧密相关，尽管这个问题仍未解决。为了评估循环T和神经类固醇敏感性在预测行为中的相对重要性，我们测量了自由活动的雄性和雌性黑眼（Junco hyemalis）分阶段侵入过程中的侵略性。我们比较了行为相关脑区域（禽内侧杏仁核，下丘脑和歌曲控制区域）中血浆T水平和雄激素受体（AR），芳香化酶（AROM）和雌激素受体α（ORα）mRNA的丰度。我们还询问男性和女性的行为和内分泌参数之间的协变量模式是否不同，因此预期循环T可能比女性更好地预测行为。我们发现循环T仅与男性的侵略性有关，但是ORα，AR和AROM的基因表达与男女的侵略性个体差异共变。这些发现是第一个表明三种主要的性类固醇加工分子的神经基因表达的个体差异预示着自然界中两性侵略性的个体差异。结果对我们理解攻击行为可能演变的机制具有广泛的意义。

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