首页> 美国卫生研究院文献>BMC Cancer >An overview of cancer/testis antigens expression in classical Hodgkins lymphoma (cHL) identifies MAGE-A family and MAGE-C1 as the most frequently expressed antigens in a set of Brazilian cHL patients
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An overview of cancer/testis antigens expression in classical Hodgkins lymphoma (cHL) identifies MAGE-A family and MAGE-C1 as the most frequently expressed antigens in a set of Brazilian cHL patients

机译:概述经典霍奇金淋巴瘤(cHL)中的癌症/睾丸抗原表达确定MAGE-A家族和MAGE-C1是一组巴西cHL患者中表达最频繁的抗原

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摘要

BackgroundCancer/testis antigens are considered potential targets for immunotherapy due to their tumor-associated expression pattern. Although recent studies have demonstrated high expression of CT45 in classical Hodgkin's lymphomas (cHL), less is known about the expression pattern of other families of CTAs in cHL. We aim to evaluate the expression of MAGE-A family, MAGE-C1/CT7, MAGE-C2/CT10, NY-ESO1 and GAGE family in cHL and to correlate their expression with clinical and prognostic factors in cHL.
机译:背景癌/睾丸抗原由于其与肿瘤相关的表达方式而被认为是免疫治疗的潜在靶标。尽管最近的研究表明经典霍奇金淋巴瘤(cHL)中CT45的高表达,但对cHL中其他CTA家族表达模式的了解却很少。我们旨在评估cHL中MAGE-A家族,MAGE-C1 / CT7,MAGE-C2 / CT10,NY-ESO1和GAGE家族的表达,并将其表达与cHL中的临床和预后因素相关联。

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