首页> 美国卫生研究院文献>BMC Cancer >A phase II randomized placebo-controlled double-blind study of salvage radiation therapy plus placebo versus SRT plus enzalutamide with high-risk PSA-recurrent prostate cancer after radical prostatectomy (SALV-ENZA)

【2h】

A phase II randomized placebo-controlled double-blind study of salvage radiation therapy plus placebo versus SRT plus enzalutamide with high-risk PSA-recurrent prostate cancer after radical prostatectomy (SALV-ENZA)

机译：根治性前列腺切除术后高危PSA复发前列腺癌（SALV-ENZA）的挽救性放疗联合安慰剂与SRT联合恩杂鲁胺的II期随机安慰剂对照双盲研究

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

BackgroundIn men with a rising PSA following radical prostatectomy, salvage radiation therapy (SRT) offers a second chance for cure. Hormonal therapy can be combined with SRT in order to increase prostate tumor control, albeit with associated higher rates of treatment side effects. This trial studies the effectiveness of SRT combined with hormonal therapy using a more potent anti-androgen with a favorable side effect profile. Enzalutamide, a next generation selective androgen receptor antagonist, is approved by the Food and Drug Administration for the treatment of metastatic castrate-resistant prostate cancer (CRPC) where it has been shown to improve overall survival in combination with androgen deprivation therapy. The primary objective of this study is to evaluate the efficacy of combination SRT and enzalutamide for freedom-from-PSA-progression. Secondary objectives include time to local recurrence within the radiation field, metastasis-free survival and safety as determined by frequency and severity of adverse events.

机译：背景对于前列腺癌根治术后PSA升高的男性，抢救性放射治疗（SRT）提供了第二次治愈机会。激素治疗可以与SRT结合使用，以增加对前列腺肿瘤的控制，尽管伴随有更高的治疗副作用率。该试验研究了使用更有效的抗雄激素和副作用良好的激素疗法联合SRT的有效性。 Enzalutamide是一种下一代选择性雄激素受体拮抗剂，已获得美国食品药品监督管理局（FDA）的批准，可用于治疗转移性去势抵抗性前列腺癌（CRPC），并已证明与雄激素剥夺疗法相结合可提高总体生存率。这项研究的主要目的是评估SRT和enzalutamide联合使用对摆脱PSA进展的功效。次要目标包括放疗区域内局部复发的时间，无转移生存率和安全性（由不良事件的发生频率和严重程度决定）。

著录项

期刊名称 BMC Cancer
作者
Roche Kapoor; Matthew P. Deek; Riley McIntyre; Natasha Raman; Megan Kummerlowe; Iyah Chen; Matt Gaver; Hao Wang; Sam Denmeade; Tamara Lotan; Channing Paller; Mark Markowski; Michael Carducci; Mario Eisenberger; Tomasz M. Beer; Daniel Y. Song; Theodore L. DeWeese; Jason W. Hearn; Stephen Greco; Curtiland DeVille; Neil B. Desai; Elisabeth I. Heath; Stanley Liauw; Daniel E. Spratt; Arthur Y. Hung; Emmanuel S. Antonarakis; Phuoc T. Tran;
展开▼
作者单位

展开▼
年(卷),期 2019(19),-1
年度 2019
页码 572
总页数 10
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Recurrent prostate cancer Salvage radiation therapy (SRT) High-risk prostate cancer Enzalutamide Prostatectomy;

机译：复发性前列腺癌;抢救性放射治疗（SRT）;高危前列腺癌;恩杂鲁胺;前列腺切除术;

相似文献

外文文献
中文文献
专利

1. A phase II randomized placebo-controlled double-blind study of salvage radiation therapy plus placebo versus SRT plus enzalutamide with high-risk PSA-recurrent prostate cancer after radical prostatectomy (SALV-ENZA) [J] . Roche Kapoor, Matthew P. Deek, Riley McIntyre, BMC Cancer . 2019,第1期

机译：A II期随机安慰剂控制的拯救治疗加安慰剂与SRT加上苯甲胺酰胺的双盲研究与高风险的PSA-复发前列腺癌（Salv-enza）
2. Effects of concentrated long-chain omega-3 polyunsaturated fatty acid supplementation before radical prostatectomy on prostate cancer proliferation, inflammation, and quality of life: study protocol for a phase IIb, randomized, double-blind, placebo-controlled trial [J] . Marie-Hélène Guertin, Karine Robitaille, Jean-Fran?ois Pelletier, BMC Cancer . 2018,第1期

机译：前列腺癌根治术前补充浓长链omega-3多不饱和脂肪酸对前列腺癌增殖，炎症和生活质量的影响：IIb期，随机，双盲，安慰剂对照试验的研究方案
3. Veterans Affairs Cooperative Studies Program Study 553: Chemotherapy After Prostatectomy, a Phase III Randomized Study of Prostatectomy Versus Prostatectomy with Adjuvant Docetaxel for Patients with High-Risk, Localized Prostate Cancer [J] . Bruce Montgomery, Philip Lavori, Mark Garzotto, Urology . 2008,第3期

机译：退伍军人事务合作研究计划研究553：前列腺切除术后的化学治疗，一项针对前列腺癌高危，局部前列腺癌患者的前列腺切除术与多西紫杉醇联合前列腺切除术的三期随机研究
4. Vascular-Targeted Photodynamic of Prostate Cancer Phase with Tookad for Recurrent Prostate Cancer Following Radiation Therapy: Initial Clinical Studies [C] . Robert A. Weersink, Brian C. Wilson, Arjen Bogaards, Photonic Therapeutics and Diagnostics III; Progress in Biomedical Optics and Imaging; vol.8 no.1; Proceedings of SPIE-The International Society for Optical Engineering; vol.6424 . 2007

机译：Tookad用于前列腺癌放疗后复发性前列腺癌的血管靶向光动力学研究：初步临床研究
5. Importance of the site of positive surgical margin in salvage external beam radiation therapy for biochemical recurrence of prostate cancer after radical prostatectomy [D] . KASHIHARA, Tairo 2019

机译：前列腺癌根治术后前列腺癌生化复发的挽救性外照射治疗中手术切缘阳性部位的重要性
6. Effects of concentrated long-chain omega-3 polyunsaturated fatty acid supplementation before radical prostatectomy on prostate cancer proliferation inflammation and quality of life: study protocol for a phase IIb randomized double-blind placebo-controlled trial [O] . Marie-Hélène Guertin, Karine Robitaille, Jean-François Pelletier, 2018

机译：前列腺癌根治术前补充浓长链omega-3多不饱和脂肪酸对前列腺癌增殖炎症和生活质量的影响：IIb期随机双盲安慰剂对照试验的研究方案
7. A randomized, double-blind, placebo-controlled phase II study of maintenance therapy with tasquinimod in patients with metastatic castration-resistant prostate cancer responsive to or stabilized during first-line docetaxel chemotherapy [O] . K. Fizazi, A. Ulys, L. Sengeløv, 2017

机译：随机，双盲，安慰剂对照期II研究患者维持治疗患者维持治疗患者转移性阉割抗阉割前列腺癌患者响应或稳定在一线多西紫杉醇化疗期间

A phase II randomized placebo-controlled double-blind study of salvage radiation therapy plus placebo versus SRT plus enzalutamide with high-risk PSA-recurrent prostate cancer after radical prostatectomy (SALV-ENZA)

摘要

著录项

相似文献

相关主题

期刊订阅