首页> 美国卫生研究院文献>BMC Biotechnology >Thermochemotherapy effect of nanosized As2O3/Fe3O4 complex on experimental mouse tumors and its influence on the expression of CD44v6 VEGF-C and MMP-9
【2h】

Thermochemotherapy effect of nanosized As2O3/Fe3O4 complex on experimental mouse tumors and its influence on the expression of CD44v6 VEGF-C and MMP-9

机译:纳米As2O3 / Fe3O4复合物对实验小鼠肿瘤的热化学治疗作用及其对CD44v6VEGF-C和MMP-9表达的影响

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

BackgroundBoth thermotherapy and arsenic have been shown to be active against a broad spectrum of cancers. To reduce the limitations of conventional thermotherapy, improve therapeutic anticancer activity, reduce the toxicity of arsenic on normal tissue, and increase tissue-specific delivery, we prepared a nanosized As2O3/Fe3O4 complex (Fe3O4 magnetic nanoparticles encapsulated in As2O3). We assessed the thermodynamic characteristics of this complex and validated the hyperthermia effect, when combined with magnetic fluid hyperthermia (MFH), on xenograft HeLa cells (human cervical cancer cell line) in nude mice. We also measured the effect on the expression of CD44v6, VEGF-C, and MMP-9 which were related to cancer and/or metastasis.
机译:背景技术热疗法和砷都被证明对多种癌症具有活性。为了减少常规热疗法的局限性,提高治疗性抗癌活性,降低砷对正常组织的毒性并增加组织特异性递送,我们制备了纳米级As2O3 / Fe3O4复合物(Fe3O4磁性纳米颗粒封装在As2O3中)。我们评估了这种复合物的热力学特征,并与磁流体热疗(MFH)结合使用,验证了对裸鼠异种移植HeLa细胞(人宫颈癌细胞系)的热疗效果。我们还测量了对与癌症和/或转移有关的CD44v6,VEGF-C和MMP-9表达的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号