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首页> 美国卫生研究院文献>The Journal of Neuroscience >Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. II. Adaptation to chronically presented stressful stimuli
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Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. II. Adaptation to chronically presented stressful stimuli

机译：自由移动的猫的蓝斑中去甲肾上腺素能神经元的单单位反应。二。适应长期呈现的压力刺激

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The preceding paper described a stress-related tonic activation of noradrenergic neurons of the locus coeruleus (LC) of behaving cats. The present study examined the degree to which adaptation to stress was reflected in LC unit activity. Adaptation was defined as a reduction in the magnitude of the physiological stress response of the animal, as reflected in plasma norepinephrine level and heart rate. Adaptation of the physiological stress response occurred after 5 repeated hourly presentations of 100 dB white noise and after 2 hr of restraint. When these stimuli ceased to elicit significant sympathoadrenal activation, they likewise ceased to elicit activation of LC single-unit activity. These results provide further support for the hypothesis that tonic elevations in LC neuronal activity are stress related and that the LC is involved in the CNS response to challenges to the organism.
机译：先前的论文描述了行为相关的猫的蓝斑（LC）的去甲肾上腺素能神经元的应力相关性强直激活。本研究检查了LC单元活动中对压力适应的反映程度。适应性定义为动物的生理应激反应程度的降低，反映在血浆去甲肾上腺素水平和心率上。每小时重复出现5次100 dB白噪声和2小时约束后，生理应激反应就会适应。当这些刺激停止引起明显的交感肾上腺激活时，它们同样停止引起LC单单位活性的激活。这些结果为以下假设提供了进一步的支持：LC神经元活动中的补品升高与压力有关，并且LC参与了中枢神经系统对生物体攻击的反应。

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