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首页> 外文期刊>The European Journal of Neuroscience >Single-unit responses of serotonergic medullary raphe neurons to cardiovascular challenges in freely moving cats.
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Single-unit responses of serotonergic medullary raphe neurons to cardiovascular challenges in freely moving cats.

机译：血清素能神经元神经元对自由移动猫的心血管挑战的单反应。

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摘要

Single-unit activity of serotonergic neurons in the nuclei raphe obscurus (NRO) and raphe pallidus (NRP) were recorded in conjunction with heart rate in freely moving cats in response to systemic administration of vasoactive drugs and to graded haemorrhage. Bolus administration of phenylephrine hydrochloride and sodium nitroprusside (20 microg/kg, i.v.) produced a marked, transient reflex bradycardia (-42 b.p.m.) and tachycardia (+60 b.p.m.), respectively. The activity of NRO/NRP serotonergic neurons remained unchanged after phenylephrine and nitroprusside administration. The administration of hydralazine (1 mg/kg, i.v.), a long-acting vasodilator, produced sustained tachycardia (+60 b.p.m.), which was not accompanied by changes in neuronal activity, despite prolonged reflex activation of the sympathetic nervous system. The initial withdrawal of up to 15% of total blood volume increased heart rate (+12 b.p.m.), whereas the removal of 22.5% of total blood decreased heart rate (-44 b.p.m.). The activity of NRO/NRP serotonergic neurons remained unaltered throughout graded haemorrhage trials, despite the changes in sympathetic outflow. Thus, serotonergic NRO and NRP neurons appear to be insensitive to alterations in blood pressure and baroreceptor activity, and this lack of responsiveness does not support a specific role for these cells in cardiovascular regulation. Furthermore, these neurons do not appear to be involved in physiological mechanisms underlying alterations in autonomic outflow invoked by hypertension and hypotension. Taken within the context of our previous work, the present data suggest that medullary serotonergic neurons may modulate autonomic outflow, but only in relation to their primary role in motor control.
机译：在全身运动的血管活性药物反应和分级性出血的反应中，记录了自由移动猫的核中，隐匿性睑裂（NRO）和苍白睑裂状（NRP）中的血清素能神经元的单单位活性。注射苯肾上腺素盐酸盐和硝普钠（20 microg / kg，静脉注射）的Bolus分别产生明显的短暂性反射性心动过缓（-42 b.p.m.）和心动过速（+60 b.p.m.）。服用去氧肾上腺素和硝普钠后，NRO / NRP血清素能神经元的活性保持不变。长效血管扩张剂肼苯哒嗪（1 mg / kg，静脉内）的给药产生持续的心动过速（+60 b.p.m.），尽管交感神经系统的反射激活时间延长，但神经元活动没有改变。最初最多撤出总血量的15％会增加心率（+12 b.p.m.），而撤出总血的22.5％会降低心率（-44 b.p.m.）。尽管有同感外流的改变，但在整个分级出血试验中，NRO / NRP血清素能神经元的活性均未改变。因此，血清素能NRO和NRP神经元似乎对血压和压力感受器活动的变化不敏感，并且这种缺乏响应能力的现象不支持这些细胞在心血管调节中的特定作用。此外，这些神经元似乎不参与由高血压和低血压引起的自主神经流出改变的生理机制。在我们先前工作的背景下，目前的数据表明，髓质性血清神经能神经元可以调节自主神经流出，但仅与它们在运动控制中的主要作用有关。

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