• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>BioMed Research International >Dietary Mercury Exposure Resulted in Behavioral Differences in Mice Contaminated with Fish-Associated Methylmercury Compared to Methylmercury Chloride Added to Diet
【2h】

Dietary Mercury Exposure Resulted in Behavioral Differences in Mice Contaminated with Fish-Associated Methylmercury Compared to Methylmercury Chloride Added to Diet

机译：与添加到饮食中的甲基汞相比饮食中汞暴露导致鱼相关甲基汞污染的小鼠行为差异

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Methylmercury (MeHg) is a potent neurotoxin, and humans are mainly exposed to this pollutant through fish consumption. However, in classical toxicological studies, pure methylmercury chloride (MeHgCl) is injected, given to drink or incorporated within feed assuming that its effects are identical to those of MeHg naturally associated to fish. In the present study, we wanted to address the question whether a diet containing MeHg associated to fish could result in observable adverse effects in mice as compared to a diet containing the same concentration of MeHg added pure to the diet and whether beneficial nutriments from fish were able to counterbalance the deleterious effects of fish-associated mercury, if any. After two months of feeding, the fish-containing diet resulted in significant observable effects as compared to the control and MeHg-containing diets, encompassing altered behavioral performances as monitored in a Y-shaped maze and an open field, and an increased dopamine metabolic turnover in hippocampus, despite the fact that the fish-containing diet was enriched in polyunsaturated fatty acids and selenium compared to the fish-devoid diets.
机译：甲基汞（MeHg）是一种有效的神经毒素，人类主要通过食用鱼类来暴露于这种污染物。但是，在经典毒理学研究中，假定纯甲基氯化汞（MeHgCl）的作用与鱼类天然产生的MeHg的作用相同，则将其注射，饮用或掺入饲料中。在本研究中，我们要解决的问题是，与含有与鱼类相关的MeHg的饮食相比，向饮食中添加相同浓度的纯MeHg的饮食，是否可以对小鼠产生可观察到的不良影响？能够抵消与鱼类相关的汞（如果有）的有害影响。喂食两个月后，与对照和含MeHg的饮食相比，含鱼的饮食产生了可观察到的显着效果，包括在Y型迷宫和开阔的田野中监测到的行为表现改变，以及多巴胺代谢转换增加尽管无鱼饮食与含鱼饮食相比富含多不饱和脂肪酸和硒，但在海马中却是如此。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号