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Optical Microfibre Based Photonic Components and Their Applications in Label-Free Biosensing

机译:基于光学微纤维的光子组件及其在无标签生物传感中的应用

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摘要

Optical microfibre photonic components offer a variety of enabling properties, including large evanescent fields, flexibility, configurability, high confinement, robustness and compactness. These unique features have been exploited in a range of applications such as telecommunication, sensing, optical manipulation and high Q resonators. Optical microfibre biosensors, as a class of fibre optic biosensors which rely on small geometries to expose the evanescent field to interact with samples, have been widely investigated. Due to their unique properties, such as fast response, functionalization, strong confinement, configurability, flexibility, compact size, low cost, robustness, ease of miniaturization, large evanescent field and label-free operation, optical microfibres based biosensors seem a promising alternative to traditional immunological methods for biomolecule measurements. Unlabeled DNA and protein targets can be detected by monitoring the changes of various optical transduction mechanisms, such as refractive index, absorption and surface plasmon resonance, since a target molecule is capable of binding to an immobilized optical microfibre. In this review, we critically summarize accomplishments of past optical microfibre label-free biosensors, identify areas for future research and provide a detailed account of the studies conducted to date for biomolecules detection using optical microfibres.
机译:光学微纤维光子组件提供了多种使能特性,包括大的渐逝场,灵活性,可配置性,高封闭性,坚固性和紧凑性。这些独特的功能已在电信,传感,光学操纵和高Q谐振器等一系列应用中得到了利用。光学微纤维生物传感器是一类依赖于小几何形状来暴露van逝场以与样品相互作用的光学纤维生物传感器。由于其独特的特性,例如快速响应,功能化,牢固的封闭性,可配置性,灵活性,紧凑的尺寸,低成本,鲁棒性,易于小型化,大的渐逝场和无标签操作,基于光学微纤维的生物传感器似乎是有希望的替代品用于生物分子测量的传统免疫学方法。由于目标分子能够结合固定的光学微纤维,因此可以通过监控各种光学转导机制(例如折射率,吸收和表面等离振子共振)的变化来检测未标记的DNA和蛋白质目标。在这篇综述中,我们批判性地总结了过去的无光学标签的生物传感器的成就,确定了未来的研究领域,并详细介绍了迄今为止使用光学微纤维进行生物分子检测的研究。

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