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首页> 美国卫生研究院文献>Biosensors >Integrated Microfluidic Devices Fabricated in Poly (Methyl Methacrylate) (PMMA) for On-site Therapeutic Drug Monitoring of Aminoglycosides in Whole Blood
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Integrated Microfluidic Devices Fabricated in Poly (Methyl Methacrylate) (PMMA) for On-site Therapeutic Drug Monitoring of Aminoglycosides in Whole Blood

机译：聚甲基丙烯酸甲酯（PMMA）制造的集成微流控设备用于全血中氨基糖苷的现场治疗药物监测

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On-site therapeutic drug monitoring (TDM) is important for providing a quick and accurate dosing to patients in order to improve efficacy and minimize toxicity. Aminoglycosides such as amikacin, gentamicin, and tobramycin are important antibiotics that have been commonly used to treat infections of chronic bacterial infections in the urinary tract, lung, and heart. However, these aminoglycosides can lead to vestibular and auditory dysfunction. Therefore, TDM of aminoglycosides is important due to their ototoxicity and nephrotoxicity. Here, we have developed a hot embossed poly (methyl methacrylate) (PMMA) microfluidic device featuring an electrokinetic size and mobility trap (SMT) to purify, concentrate, and separate the aminoglycoside antibiotic drugs amikacin, gentamicin, and tobramycin. These drugs were separated successfully from whole blood within 3 min, with 30-fold lower detection limits compared to a standard pinched injection. The limit of detections (LOD) were 3.75 µg/mL for gentamicin, 8.53 µg/mL for amikacin, and 6.00 µg/mL for tobramycin. These are sufficient to cover the therapeutic range for treating sepsis of 6–10 μg/mL gentamicin and tobramycin and 12–20 μg/mL of amikacin. The device is simple and could be mass produced via embossing or injection molding approaches.
机译：现场治疗药物监测（TDM）对于向患者提供快速准确的剂量以提高疗效和最大程度地降低毒性至关重要。氨基糖苷类如阿米卡星，庆大霉素和妥布霉素是重要的抗生素，通常已用于治疗尿路，肺和心脏的慢性细菌感染。然而，这些氨基糖苷类会导致前庭和听觉功能障碍。因此，氨基糖苷的TDM由于其耳毒性和肾毒性而重要。在这里，我们开发了一种热压纹聚甲基丙烯酸甲酯（PMMA）微流控设备，该设备具有电动尺寸和迁移率阱（SMT），可纯化，浓缩和分离氨基糖苷类抗生素药物阿米卡星，庆大霉素和妥布霉素。这些药物在3分钟内成功地从全血中分离出来，与标准捏合注射相比，其检测限低30倍。庆大霉素的检出限（LOD）为3.75 µg / mL，丁胺卡那霉素为8.53 µg / mL，妥布霉素为6.00 µg / mL。这些足以覆盖治疗脓毒症6-10μg/ mL庆大霉素和妥布霉素以及12-20μg/ mL阿米卡星的治疗范围。该装置很简单，可以通过压印或注塑方法大量生产。

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