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首页> 美国卫生研究院文献>Biophysical Journal >Pulsatile signaling in intercellular communication. Periodic stimuli are more efficient than random or chaotic signals in a model based on receptor desensitization.
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Pulsatile signaling in intercellular communication. Periodic stimuli are more efficient than random or chaotic signals in a model based on receptor desensitization.

机译：细胞间通讯中的脉冲信号。在基于受体脱敏的模型中周期性刺激比随机或混沌信号更有效。

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摘要

The efficiency of various patterns of pulsatile stimulation is determined in a model in which a receptor becomes desensitized in the presence of its stimulatory ligand. The effect of stochastic or chaotic changes in the duration and/or interval between successive pulses in a series of square-wave stimuli is investigated. Before addressing the effect of random variations in the pulsatile signal, we first extend the results of a previous analysis (Li, Y.X., and A. Goldbeter. 1989. Biophys. J. 55:125-145) by demonstrating the existence of an optimal periodic signal that maximizes target cell responsiveness whatever the magnitude of stimulation. As to the effect of stochastic or chaotic variations in the pulsatile stimulus, three kinds of random distributions are used, namely, a Gaussian and a white-noise distribution, and a chaotic time series generated by the logistic map. All these random distributions are symmetrically centered around the reference value of the duration or interval that characterizes the optimal periodic stimulus yielding maximal responsiveness in target cells. Stochastically or chaotically varying pulses are less effective than the periodic signal that corresponds to the optimal pattern of pulsatile stimulation. The response of the receptor system is most sensitive to changes in the time interval that separates successive stimuli. Similar conclusions hold when stochastic or chaotic signals are compared to a reference periodic stimulus differing from the optimal one, although the effect of random variations is then reduced. The decreased efficiency of stochastic pulses accounts for the observed superiority of periodic versus stochastic pulses of cyclic AMP (cAMP) in Dictyostelium amoebae. The results are also discussed with respect to the efficiency of periodic versus stochastic or chaotic patterns of hormone secretion.
机译：在其中受体在其刺激性配体存在下变得脱敏的模型中确定各种搏动刺激模式的效率。研究了一系列方波刺激中连续脉冲之间的持续时间和/或间隔的随机或混沌变化的影响。在解决脉动信号中随机变化的影响之前，我们首先通过证明最优解的存在来扩展先前分析的结果（Li，YX和A. Goldbeter。1989. Biophys。J. 55：125-145）。周期性的信号，无论刺激的大小如何，均可最大化靶细胞的反应能力。关于脉动刺激中的随机或混沌变化的影响，使用了三种随机分布，即高斯分布和白噪声分布，以及由逻辑图生成的混沌时间序列。所有这些随机分布都围绕持续时间或间隔的参考值对称居中，该参考值表征了最佳周期性刺激，从而在靶细胞中产生最大响应。随机或无序变化的脉冲比对应于脉动刺激的最佳模式的周期性信号的效果差。受体系统的反应对分隔连续刺激的时间间隔的变化最敏感。将随机信号或混沌信号与不同于最佳信号的参考周期性刺激进行比较时，尽管可以减少随机变化的影响，但得出类似的结论。随机脉冲效率的降低解释了变形杆菌属中周期性AMP相对于随机脉冲AMP（cAMP）的优越性。还就激素分泌的周期性，随机或混沌模式的效率进行了讨论。

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